In the Brave New World of my fable there was no whisky, no tobacco, no illicit heroin, no bootlegged co­caine. People neither smoked, nor drank, nor sniffed, nor gave themselves injections. Whenever anyone felt depressed or below par, he would swallow a tablet or two of a chemical compound called soma. The original soma, from which I took the name of this hypothetical drug, was an unknown plant (possibly Asclepias aeida) used by the ancient Aryan invaders of India in one of the most solemn of their religious rites. The intoxicating juice expressed from the stems of this plant was drunk by the priests and nobles in the course of an elaborate ceremony. In the Vedic hymns we are told that the drinkers of soma were blessed in many ways. Their bodies were strengthened, their hearts were filled with courage, joy and enthusiasm, their minds were enlightened and in an immediate ex­perience of eternal life they received the assurance of their immortality. But the sacred juice had its draw­backs. Soma was a dangerous drug — so dangerous that even the great sky-god, Indra, was sometimes made ill by drinking it. Ordinary mortals might even die of an overdose. But the experience was so transcendently blissful and enlightening that soma drinking was regarded as a high privilege. For this privilege no price was too great.

The soma of Brave New World had none of the draw­backs of its Indian original. In small doses it brought a sense of bliss, in larger doses it made you see visions and, if you took three tablets, you would sink in a few minutes into refreshing sleep. And all at no physiologi­cal or mental cost. The Brave New Worlders could take holidays from their black moods, or from the familiar annoyances of everyday life, without sacrificing their health or permanently reducing their efficiency.

In the Brave New World the soma habit was not a private vice; it was a political institution, it was the very essence of the Life, Liberty and Pursuit of Happiness guaranteed by the Bill of Rights. But this most precious of the subjects' inalienable privileges was at the same time one of the most powerful instruments of rule in the dictator's armory. The systematic drugging of individuals for the benefit of the State (and inciden­tally, of course, for their own delight) was a main plank in the policy of the World Controllers. The daily soma ration was an insurance against personal malad­justment, social unrest and the spread of subversive ideas. Religion, Karl Marx declared, is the opium of the people. In the Brave New World this situation was reversed. Opium, or rather soma, was the people's reli­gion. Like religion, the drug had power to console and compensate, it called up visions of another, better world, it offered hope, strengthened faith and pro­moted charity. Beer, a poet has written,

. . .does more than Milton can

To justify God's ways to man.

And let us remember that, compared with soma, beer is a drug of the crudest and most unreliable kind. In this matter of justifying God's ways to man, soma is to alcohol as alcohol is to the theological arguments of Milton.

In 1931, when I was writing about the imaginary synthetic by means of which future generations would be made both happy and docile, the well-known Ameri­can biochemist, Dr. Irvine Page, was preparing to leave Germany, where he had spent the three preced­ing years at the Kaiser Wilhelm Institute, working on the chemistry of the brain. "It is hard to understand," Dr. Page has written in a recent article, "why it took so long for scientists to get around to investigating the chemical reactions in their own brains. I speak," he adds, "from acute personal experience. When I came home in 1931 . . . I could not get a job in this field (the field of brain chemistry) or stir a ripple of interest in it." Today, twenty-seven years later, the non-existent ripple of 1931 has become a tidal wave of biochemical and psychopharmacological research. The enzymes which regulate the workings of the brain are being studied. Within the body, hitherto unknown chemical substances such as adrenochrome and serotonin (of which Dr. Page was a co-discoverer) have been isolated and their far-reaching effects on our mental and physical functions are now being investigated. Meanwhile new drugs are being synthesized — drugs that reinforce or correct or interfere with the actions of the various chemicals, by means of which the nervous system performs its daily and hourly miracles as the controller of the body, the instrument and medi­ator of consciousness. From our present point of view, the most interesting fact about these new drugs is that they temporarily alter the chemistry of the brain and the associated state of the mind without doing any permanent damage to the organism as a whole. In this respect they are like soma — and profoundly unlike the mind-changing drugs of the past. For example, the classical tranquillizer is opium. But opium is a dangerous drug which, from neolithic times down to the present day, has been making addicts and ruining health. The same is true of the classical euphoric, alco­hol — the drug which, in the words of the Psalmist, "maketh glad the heart of man." But unfortunately alcohol not only maketh glad the heart of man; it also, in excessive doses, causes illness and addiction, and has been a main source, for the last eight or ten thou­sand years, of crime, domestic unhappiness, moral deg­radation and avoidable accidents.

Among the classical stimulants, tea, coffee and mate are, thank goodness, almost completely harmless. They are also very weak stimulants. Unlike these "cups that cheer but not inebriate," cocaine is a very powerful and a very dangerous drug. Those who make use of it must pay for their ecstasies, their sense of unlimited physical and mental power, by spells of agonizing depression, by such horrible physical symptoms as the sensation of being infested by myriads of crawling insects and by paranoid delusions that may lead to crimes of violence. Another stimulant of more recent vintage is amphetamine, better known under its trade name of Benzedrine. Amphetamine works very effec­tively — but works, if abused, at the expense of mental and physical health. It has been reported that, in Ja­pan, there are now about one million amphetamine ad­dicts.

Of the classical vision-producers the best known are the peyote of Mexico and the southwestern United States and Cannabis sativa, consumed all over the world under such names as hashish, bhang, kif and marihuana. According to the best medical and anthro­pological evidence, peyote is far less harmful than the White Man's gin or whisky. It permits the Indians who use it in their religious rites to enter paradise, and to feel at one with the beloved community, without making them pay for the privilege by anything worse than the ordeal of having to chew on something with a revolting flavor and of feeling somewhat nauseated for an hour or two. Cannabis sativa is a less innocuous drug — though not nearly so harmful as the sen­sation-mongers would have us believe. The Medical Committee, appointed in 1944 by the Mayor of New York to investigate the problem of marihuana, came to the conclusion, after careful investigation, that Can­nabis sativa is not a serious menace to society, or even to those who indulge in it. It is merely a nuisance.

From these classical mind-changes we pass to the latest products of psychopharmacological research. Most highly publicized of these are the three new tranquillizers, reserpine, chlorpromazine and meprobamate. Administered to certain classes of psychotics, the first two have proved to be remarkably effective, not in curing mental illnesses, but at least in temporarily abolishing their more distressing symptoms. Meproba­mate (alias Miltown) produces similar effects in per­sons suffering from various forms of neurosis. None of these drugs is perfectly harmless; but their cost, in terms of physical health and mental efficiency, is ex­traordinarily low. In a world where nobody gets any­thing for nothing tranquillizers offer a great deal for very little. Miltown and chlorpromazine are not yet soma; but they come fairly near to being one of the aspects of that mythical drug. They provide temporary relief from nervous tension without, in the great ma­jority of cases, inflicting permanent organic harm, and without causing more than a rather slight im­pairment, while the drug is working, of intellectual and physical efficiency. Except as narcotics, they are probably to be preferred to the barbiturates, which blunt the mind's cutting edge and, in large doses, cause a number of undesirable psychophysical symp­toms and may result in a full-blown addiction.