I am greatly indebted to the employees and medical staff of the Massachusetts General Hospital for a kindness and patience that went beyond any reasonable expectation.

I would also like to thank Drs. Robert Ebert, Hermann Lisco, Joseph Gardella, and Mr. Jerome Pollock, all of the Harvard Medical School, for encouragement and advice in planning the book; Drs. Howard Hiatt, Charles Huggins, Hugh Chandler, Ashby Moncure, James Feeney, Joel Alpert, Edward Shapiro, Josef Fisher, Michael Soper, Jerry Grossman, and Miss Kathleen Dwyer for their suggestions at various points in my work; Drs. Alexander Leaf, Martin Nathan, Jonas Salk, and Mr. Martin Bander for their review of the manuscript at different points; Mr. Robert Gottlieb and Miss Lynn Nesbit for ongoing, tireless work on the project; and finally Dr. John Knowles, whose influence is everywhere in this book, as it is in the hospital he directs. With all this help, the book ought to be flawless, and to the extent that it is not, I am to blame.

Acknowledgments

The late Alan Gregg once quoted a former teacher as saying, "Whenever you say anything explicitly to anyone, you also say something else implicitly, namely, that you think you are the guy to say it." Such sentiments trouble all but the most egotistical writers; the others recognize that their sense of enfranchisement is a gift of the people around them, whom they can only hope not to disappoint.