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Dental Management of Sleep Disorders focuses on the dentist’s role in treating patients with sleep problems, chiefly sleep disordered breathing and bruxism. A practical clinical book, Dental Management of Sleep Disorders highlights the background to these problems, discusses the dentist’s role in their diagnosis and treatment, and outlines clinical strategies and guidance. The book features a full discussion of the use of appliances, an overview of current treatment modalities, and investigates the relationship of sleep disorders to dental and orofacial causes.

This new book by international experts in psycho-oncology has arisen from the teaching academies offered by the International Psycho-oncology Society. It distills the wisdom and experience from the training manuals dedicated to individual psychological therapies and combines them into an accessible handbook for clinicians in cancer care today. The editors have brought together leading researchers and therapists, who provide accounts of the prominent models of psychotherapy currently being used in cancer care, the key themes they address and the essential techniques needed to apply each approach successfully. Helpful clinical illustrations are woven throughout the book to make overt the strategies found in each model. Provides practical guidance about how to deliver a range of individual, group, couple and family interventions that have proven utility in cancer care. Describes comprehensively each model of psychotherapy as taught by experts delivering the International Psycho-Oncology Society’s Educational Academy on cancer care for patients and their families. Features practical suggestions on therapy delivery from the world’s leading proponents of each therapy. Serves as a valuable tool to assist teaching and to facilitate research into psychological interventions in oncology, palliative care and bereavement. Functions as a readily accessible resource for clinicians struggling to support someone effectively, through its provision of insight into the common challenges and traps that arise when providing patients with emotional support. This practical handbook will help not only psychiatrists, psychologists and social workers but also physicians, surgeons, general practitioners and nurses interested in better understanding and supporting the patients and families they care for.

The renowned Principles and Practice of Geriatric Psychiatry, now in its third edition, addresses the social and biological concepts of geriatric mental health from an international perspective. Featuring contributions by distinguished authors from around the world, the book offers a distinctive angle on issues in this continually developing discipline. Principles and Practice of Geriatric Psychiatry provides a comprehensive review of: geriatric psychiatry spanning both psychiatric and non-psychiatric disorders scientific advances in service development specific clinical dilemmas New chapters on: genetics of aging somatoform disorders epidemiology of substance abuse somatoform disorders care of the dying patient Continuing the practice of earlier editions, the major sections of the book address aging, diagnosis and assessment and clinical conditions, incorporating an engaging discussion on substance abuse and schizophrenic disorders. Shorter sections include the presentation of mental illness in elderly people from different cultures—one of the most popular sections in previous editions. Learning and behavioural studies, as well as models of geriatric psychiatry practice, are covered extensively. This book provides a detailed overview of the entire range of mental illness in old age, presented within an accessible format. Principles and Practice of Geriatric Psychiatry is an essential read for psychiatrists, geriatricians, neurologists and psychologists. It is of particular use for instructors of general psychiatry programs and their residents.

This new edition of The Strategic Application of Information Technology in Health Care Organizations offers a peerless guide for health care leaders to understand information technology (IT) strategic planning and implementation. Filled with illustrative case studies, the book explores the link between overall strategy and information technology strategy. It discusses organizational capabilities, such as change management, that have an impact on an organization's overall IT effectiveness, and a wide range of IT strategy issues. The book covers emerging trends such as personalized medicine; service-oriented architecture; the ramification of changes in care delivery models, and the IT strategies necessary to support public health. «Health information technology sometimes masquerades as an end in itself. The reality is that IT is a means to an end, an enabler of the strategic goals of health care organizations. This volume reminds us that shaping IT strategy and implementation to an organization's goals is the key to generating both economic returns and safer care for patients. You don't need an engineer to understand how to use IT to advance a health care organization's strategic agenda. You just need to read this book.»– Jeff Goldsmith, PhD, president of Health Futures, Inc. «In this time of health care reform, nothing is more front and center than health IT. This book is an exceptional blueprint for the future, with a focus on the essential measures of success for any system implementation.» – Stephanie Reel, MBA, vice provost for information technology and chief information officer, The Johns Hopkins University «In this book, the authors answer the question that every health care leader should be asking: How do we unlock the promise of health information technology and fundamentally reshape our industry? This is a must-read for every person who wants to improve American health care.» – David Brailer, MD, PhD, chairman of Health Evolution Partners

The Science of Occupational Health is an evidence-based resource for all members of the health care team working with those affected by work-based stress – whether individuals suffering physical or psychological symptoms, or organizations trying to provide optimum conditions for healthy and productive employees. The authors offer a unique psychobiological perspective, discussing the modern workplace as a cause of stimulation and well-being, as well as of distress and illness. They provide a rigorous but highly accessible scientific account of the effects that stress has on mind and body, with key chapters on 'Responses to Stress', 'Stress-Related Health Problems', and 'Stress Hormones at Work'. This book offers the reader practical guidance on health promotion and preventive strategies at both individual and organizational levels. It concludes with a discussion of present occupational conditions around the world, and predictions of likely trends in the future. Foreword by Sir Michael Marmot, University College London

Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging. • Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure • Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information • Focuses on an emerging and important area for pharmaceutical and medical applications • Encompasses technical, regulatory, and application aspects • Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control

Diabetic Foot Care: Case Studies in Clinical Management uses a 100% illustrated patient case study format to demonstrate the multidisciplinary care and clinical management of patients with feet and lower limb problems as a result of diabetes. Every case has colour illustrations highlighting both the initial presentation of the foot, right through to treatment and long term follow-up care. Of particular focus are the management problems, barriers to effective care, preventable mistakes, unnecessary delays in presentations, challenging situations, conflicts, dilemmas and solutions that podiatrists and diabetic specialists face. Sections in the book include: Neuropathic and neuroischaemic foot, neuropathic ulcers, ischaemic ulcers, infections, gangrene, traumatic injuries, Charcot's osteoarthropathy, dermatological problems associated with diabetes, painful neuropathy, diabetic foot emergencies, angiology and foot surgery/amputation. With key points and summaries at the beginning and end of each section, this book is clear and easy to navigate, making it an ideal tool for diabetes specialists, diabetes nurses and podiatrists.

This revised edition of Charles Brook's Handbook of Clinical Pediatric Endocrinology provides endocrinologists and pediatricians in training with a fully up-to-date clinical guide presenting evidence-based practice in the diagnosis, treatment, and management of pediatric endocrine disorders. New chapters include “Endocrine complications of chronic disease” and “Endocrine neoplasia.” In addition, the chapter structure has been revamped for easier access and now includes: a key points overview, multiple-choice questions for self-assessment, common errors/pitffalls (in treatment, diagnosis, etc.) boxes, a key weblinks box, a table comparing different society guidelines, diagnostic decision trees, therapeutics decision trees, and a summary.

Foundations of Health Care Management Leaders and managers throughout the health care system are facing ever more challenging changes in the way care is delivered, paid for, and evaluated. Foundations of Health Care Management: Principles and Methods offers an innovative, concise, reader-friendly introduction to health care management and administration. It addresses the need for new skills in managers of health care facilities and for those planning to enter health care management positions. The book covers such critical topics as leadership training, change management, conflict management techniques, culture building, quality improvement, and communications skills, as well as collaboration in the improvement of population health. Foundations of Health Care Management also concentrates on innovations and describes steps in the transition to more decentralized and creative approaches to the management of health care facilities. The book covers physician management from the physician's viewpoint, a valuable perspective for health care managers. The book serves important dual purposes for faculty and students by providing both insights into the health care field as well as foundational content on essential management and leadership competencies. A full set of support materials is available for instructors at the book's companion Web site.