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The ABC of Sports and Exercise Medicine provides general practitioners with a comprehensive overview of the field of sports medicine. This highly illustrated and thoroughly revised and updated new edition: • Reflects new developments and current practice • Includes new chapters on medical care at sporting events, environmental factors of sports and exercise, benefits of exercise in health and disease, nutrition and ergogenic supplements, and the use of drugs in sport • Covers the benefits of exercise among special populations such as the disabled, obese, pregnant, children and the elderly Covering the latest topics and including case studies of common sports and exercise medicine conditions, the ABC of Sports and Exercise Medicine is an essential practical guide for general practitioners, family physicians, junior doctors, medical students, physiotherapists, and all health professionals dealing with the treatment and prevention of sports-related injuries.

Do you have patients referred to you suffering from NAFLD? Are you looking for an expert guide to the latest in clinical management? If so, this is the book for you, providing an expert and comprehensive analysis of NAFLD: what it is, why it happens, who is likely to suffer from it, and how to decide on the best management options for your patients. This book focuses clearly on providing first-rate clinical guidance as to the assessment, diagnosis and treatment of patients in the clinical setting, based wherever possible on the latest evidence and scientific understanding of disease mechanisms. With each chapter fully revised and updated with the very latest in AASLD, EASL and Asia-Pacific guidelines, this second edition provides: Four brand new chapters, including “NAFLD and cardiovascular risk factors” and “Non-invasive methods to determine severity of NAFLD/ NASH” A clear overview on the causative mechanisms of NAFLD Self-assessment via key points and multiple-choice questions throughout The very latest in clinical drug trials Analysis of NAFLD in relation to obesity, diabetes, high cholesterol and liver cancer A consideration of NAFLD importance in Asia (particularly including Japan and China) and South America, as well as Europe and North America NAFLD is a serious condition that is increasing in prevalence globally from year to year. Non-Alcoholic Fatty Liver Disease: A Practical Guide, is essential reading for all hepatologists and health professionals managing patients who have this condition.

High-risk pregnancies present life-threatening challenges to two of your patients: the mother and her fetus. The direct, exemplary guidance in Protocols for High-Risk Pregnancy enables you to better understand your patients' conditions devise optimum management strategies maximize the outcome and minimize the complications for both the mother and her fetus To enhance clinical relevance, each protocol is written as if the patient were present. Evidence to support an intervention is given where it exists. The authors' experience provides additional wise counsel. Key references provide the springboard for a deeper understanding of a topic. In this more compact and fully updated sixth edition, new protocols include Amniotic fluid disorders Depression Fetal growth restriction HIV Indicated late preterm and early term birth Malaria Noninvasive prenatal diagnosis Designed for clinical practice by the leaders of two generations of maternal-fetal medicine, no obstetrician or obstetric health care provider can afford to miss Protocols for High-Risk Pregnancy.

The field of forensic archaeology has developed over recent years from being a branch of conventional archaeology into a well-established discipline in its own right. Forensic Approaches to Buried Remains takes an innovative approach to the subject by placing the role of the forensic archaeologist within the wider forensic environment; it identifies new areas of interdisciplinary research and practice, and evaluates practical difficulties. The authors see this book as a reflection of the subject’s development, and as a knowledge base for the next generation of forensic archaeologists. Areas covered include: Search logistics, integration and specialist search scenarios Levels of confidence in site search and elimination Urban and rural landscape reconstruction in both short and long term cases The integration of cadaver dogs and earth-moving machinery The recovery of multiple evidence types Sampling strategies, spatial relevance and dating Multiple burial scenarios As part of the Essential Forensic Science book series this book will provide students and practitioners alike with an invaluable resource outlining both the major developments in the discipline, as well as original approaches to the search for, and recovery of buried remains.

Advances in Intervertebral Disc Disease in Dogs and Cats defines our present knowledge of this common clinical problem, compiling information related to the canine and feline intervertebral disc into a single resource. As a comprehensive, focused work, the book is an authoritative reference for understanding and treating disc disease, providing a sound scientific and clinical basis for decision making. Offering an objective synthesis of the current literature, the book supplies guidance on the approach to a potential disc rupture, surgical and medical strategies, and management of the patient. Offering a complete understanding of intervertebral disc disease, the book describes and discusses the controversies and issues surrounding this topic, acknowledging the gaps in our knowledge. Advances in Intervertebral Disc Disease in Dogs and Cats presents up-to-date, reliable information on this common condition for veterinary surgeons, neurologists, and general practitioners.

Pollinators play a vital role in ecosystem health and are essential to ensuring food security. With declines in both managed and wild pollinator populations in recent years, scientists and regulators have sought answers to this problem and have explored implementing steps to protect pollinator populations now and for the future. Pesticide Risk Assessment for Pollinators focuses on the role pesticides play in impacting bee populations and looks to develop a risk assessment process, along with the data to inform that process, to better assess the potential risks that can accompany the use of pesticide products. Pesticide Risk Assessment for Pollinators opens with two chapters that provide a biological background of both Apis and non-Apis species of pollinators. Chapters then present an overview of the general regulatory risk assessment process and decision-making processes. The book then discusses the core elements of a risk assessment, including exposure estimation, laboratory testing, and field testing. The book concludes with chapters on statistical and modeling tools, and proposed additional research that may be useful in developing the ability to assess the impacts of pesticide use on pollinator populations. Summarizing the current state of the science surrounding risk assessment for Apis and non-Apis species, Pesticide Risk Assessment for Pollinators is a timely work that will be of great use to the environmental science and agricultural research communities. Assesses pesticide risk to native and managed pollinators Summarizes the state of the science in toxicity testing and risk assessment Provides valuable biological overviews of both Apis and non-Apis pollinators Develops a plausible overall risk assessment framework for regulatory decision making Looks towards a globally harmonized approach for pollinator toxicity and risk assessment

Backyard Poultry Medicine and Surgery is a practical resource offering guidance on developing diagnostic and treatment plans for individual companion poultry or small flocks. Organized by body system to aid in developing a differential diagnosis list for common presenting signs, the book provides all the information clinicians need to effectively treat backyard poultry. Written by experts from both the commercial poultry field and the companion avian field, the book provides thorough coverage of both common and less common diseases of backyard chickens, ducks, and other poultry. The book begins with introductory chapters covering general information, an overview of US laws, and basic husbandry concerns, then moves into specific disease chapters organized by system. The book takes an individual medicine perspective throughout, with photographs, radiographs, and histopathological photomicrographs to illustrate principles and diseases. Backyard Poultry Medicine and Surgery is an invaluable guide to diseases and treatments for any practitioners treating backyard poultry.

Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

A complete guide to understanding cluster randomised trials Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials. The book contains clear technical descriptions of the models used, and considers in detail the ethics involved in such trials and the problems in planning them. For readers and students who do not intend to run a trial but wish to be a critical reader of the literature, there are sections on the CONSORT statement, and exercises in reading published trials. Written in a clear, accessible style Features real examples taken from the authors’ extensive practitioner experience of designing and analysing clinical trials Demonstrates the use of R, Stata and SPSS for statistical analysis Includes computer code so the reader can replicate all the analyses Discusses neglected areas such as ethics and practical issues in running cluster randomised trials How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research provides an excellent reference tool and can be read with profit by statisticians, health services researchers, systematic reviewers and critical readers of cluster randomised trials.

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present «best practice» methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.

Now in full color, Practical Guide to Canine and Feline Neurology, Third Edition provides a fully updated new edition of the most complete resource on managing neurology cases in small animal practice, with video clips on a companion website.•Provides comprehensive information for diagnosing and treating neurological conditions•Printed in full color for the first time, with 400 new or improved images throughout•Offers new chapters on differential diagnosis, magnetic resonance imaging, and movement disorders•Retains the logical structure and easy-to-follow outline format of the previous editions •Includes access to video clips of specific disorders and a how-to video demonstrating the neurologic assessment online and a link to a digital canine brain atlas at www.wiley.com/go/dewey/neurologyNow in full color, Practical Guide to Canine and Feline Neurology, Third Edition provides a fully updated new edition of the most complete resource on managing neurology cases in small animal practice, with video clips on a companion website. •Provides comprehensive information for diagnosing and treating neurological conditions •Printed in full color for the first time, with 400 new or improved images throughout •Offers new chapters on differential diagnosis, magnetic resonance imaging, and movement disorders •Retains the logical structure and easy-to-follow outline format of the previous editions •Includes access to video clips of specific disorders and a how-to video demonstrating the neurologic assessment online and a link to a digital canine brain atlas at www.wiley.com/go/dewey/neurology