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Forensic medicine is a broad and evolving field with areas of rapid progress embracing both clinical and pathological aspects of practice, in which there may be considerable overlap. This is the second volume in a series that provides a unique, in-depth and critical update on selected topics of direct relevance to those practising in the field of clinical forensic medicine and related areas including lawyers, police, medical practitioners, forensic scientists, and students. The chapters endeavour to maintain a relevance to an international, multi-professional audience and include chapters on: DNA decontamination, The toxicity of novel psychoactive substances, The relevance of gastric contents in the timing of death, The effects of controlled energy devices, The main risk factors for driving impairment, The risk factors for harm to health of detainees in short-term custody, Autoerotic deaths, Child maltreatment and neglect, and The investigation of potential non-accidental head injury in children. Also included are chapters on excited delirium syndrome, automatism and personality disorders. Two topics not generally covered in standard clinical forensic medical textbooks include a forensic anthropological approach to body recovery in potential crimes against humanity and risk management and security issues for the forensic practitioner investigating potential crimes against humanity in a foreign country.

Canine Sports Medicine and Rehabilitation offers a gold-standard, comprehensive reference on all aspects of sports medicine and rehabilitation for all dogs. Written by an outstanding group of leaders in the field, the book covers topics ranging from biomechanics, exercise physiology, nutrition, and common orthopedic conditions of the canine athlete to in-depth rehabilitation and integrative therapies for all dogs. Each chapter includes case studies and numerous color images to demonstrate the concepts discussed. Encompassing basic science and integrated veterinary and physical therapy approaches, Canine Sports Medicine and Rehabilitation is a complete resource for veterinarians, physical therapists, veterinary technicians and anyone interested in working with canine athletes or in offering rehabilitation therapy in their practice.

The Textbook of Non-Medical Prescribing addresses all the key issues relevant to non-medical prescribing, bringing together essential knowledge, key issues, and skills in a single text. This accessible, engaging and comprehensive resource explores the history of non-medical prescribing; prescribing in context; ethical, legal and professional issues in relation to prescribing practice; factors influencing prescribing; effective consultations; essential pharmacology; the role of the multi-disciplinary team; clinical skills; prescribing for specific groups; and the future of nurse prescribing. With case studies throughout, The Textbook of Non-Medical Prescribing is essential reading for all students on non-medical prescribing courses. It is also of use to qualified health professionals, be they prescribers themselves or interested in the concepts of non-medical prescribing.

This practical introduction to linguistics is a must-have resource for all speech and language therapy students, providing you with the fundamental theory needed as a foundation for practice. Written by authors with extensive experience in both research and teaching, Introductory Linguistics for Speech and Language Practice equips you with a practical understanding of relevant linguistic concepts in the key language areas of morphology, syntax, semantics, discourse and pragmatics. Each chapter opens by explaining why the information is of relevance to the speech language therapist, and this integrated approach is emphasised via reference to relevant clinical resources. Exercises throughout each chapter also allow you to test your understanding of key principles and apply this knowledge to other areas of your study. This concise, readable guide is a core text for all undergraduate and postgraduate students of speech and language therapy, and is also ideal for qualified therapists wanting to enrich their understanding of the linguistic assessments they use in practice.

“This informative book has been put together with the support and input of many clinical renal experts, who have been willing to share their knowledge and years of experience and I’m sure it will be an excellent resource for those caring for kidney patients for the first time – as well as for those with some years of experience!” – From the Foreword by Rosemary Macri, Chief Executive of the British Kidney Patient Association Kidney Disease Management has been written to help optimise the care of people with chronic kidney disease (CKD) across the healthcare spectrum. It is aimed at a range of professionals, including nurses, junior doctors, general practitioners, pharmacists and dietitians. Specialists in training may also find it useful. It highlights the practical considerations necessary to care for people with kidney problems in situations where a specialist practitioner is not always required or immediately available. This book explores: policy context and CKD overview of CKD and management managing CKD in primary care treatment modalities in CKD psychosocial aspects of living with CKD Acute kidney injury in hospitalised patients surgery and kidney injury medication management in CKD nutrition and CKD support and palliative care for people with CKD Key features: Based on best practice and written in an accessible format aimed at busy practitioners Emphasises the centrality of the patient and family and the need to share information and expertise across traditional boundaries Written by professionals renowned in their field, both generalists and specialists, who have extensive experience of the practicalities of managing complex patients

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

As improvements in living conditions and advances in modern medicine lead to increased life expectancy and the number of older adults world-wide continues to grow, so the number of older individuals with cardiac and cerebrovascular disease is rising. Over eighty per cent of all cardiovascular disease-related deaths now occur in patients aged sixty five or older. The high prevalence of co-morbidities, frailty and cognitive decline amongst older patients requires that a holistic approach to the management of cardiovascular disease is required. Written and edited by leading experts in the field, ‘Cardiovascular diseases and health in the older patient’ provides scholarly evidence and data which explain why treating an older patient with cardiovascular disease is often different from treating a young or middle-aged patient with the same disease. The chapters have been updated and expanded from the cardiovascular section of the renowned ‘Pathy’s Principles and Practice of Geriatric Medicine’, edited by Alan J. Sinclair, John E. Morley and Bruno Vellas. The revised chapters contain updated evidence and references to recent clinical practice guidelines in Europe and North America, this book provides complete, authoritative information on this major cause of death, poor health and disability in old age. Covering the epidemiology, pathophysiology and management of cardiovascular disease in the older patient, the book is an excellent reference at all clinical and pre-clinical levels and will appeal particularly to geriatricians, cardiologists, and GPs, as well as cardiac specialist nurses and practice nurses. With a Foreword by Stuart M. Cobbe.

Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual ‘Clinical Trials Methodology Workshop’ for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Color Atlas of Equine Pathology offers a practical guide to identifying equine diseases, presenting a single resource with more than 1000 images showing predominantly gross pathology. Organized by body systems, the book allows for picture matching during or after an equine necropsy. In this user-friendly atlas, each chapter takes a common format, presenting the disease process as well as congenital, degenerative, inflammatory, and neoplastic sequences, with text boxes offering quick reference to key information. The book begins with an introductory chapter summarizing the principles of the equine field necropsy, and subsequent organ-based chapters depict gross features of disease, focusing on macroscopic digital images supplemented by histology and immunohistochemistry when necessary. Some clinical information for correlation with pathology is included. Color Atlas of Equine Pathology is an essential resource for diagnostic veterinary pathologists and pathology residents, as well as for equine practitioners performing necropsies in the field.

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition reflects the development within the field from an emerging subject to one that is an essential part of the assessment of clinical trials and other clinical studies. The analysis and interpretation of quality-of-life assessments relies on a variety of psychometric and statistical methods which are explained in this book in a non-technical way. The result is a practical guide that covers a wide range of methods and emphasizes the use of simple techniques that are illustrated with numerous examples, with extensive chapters covering qualitative and quantitative methods and the impact of guidelines. The material in this new third edition reflects current teaching methods and content widened to address continuing developments in item response theory, computer adaptive testing, analyses with missing data, analysis of ordinal data, systematic reviews and meta-analysis. This book is aimed at everyone involved in quality-of-life research and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and clinical practice.