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This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.

An introduction to micro and nano replication processes and applications Micro/Nano Replication: Processes and Applications provides an overview of the fundamentals, processes, and applications involved in micro and nano replication in the manufacturing of product parts. A major field of nanotechnology, the study of micro/nano replication is sure to become one of increasing importance as the construction of completely new devices based on innovative concepts and crafted at the molecular level increases. Designed to help the reader understand and learn to work with the growing number of tools for molding plastic components, the book covers the key topics related to replication, including patterning technology, the modification of mold surface properties, and much more. In addition, it addresses the strengths and weaknesses of different molding processes. With a strong focus not only on how micro/nano replication works, but also the broader implications for the industry, the book is packed with examples of real world applications. These are drawn from a variety of fields, including information storage devices, optoelectronic elements, optical communication, and biosensors, in order to provide a complete view of the importance of micro and nano processes. A valuable introduction to a new but fast-growing field, Micro/Nano Replication is an essential resource for anyone looking to get a head start on understanding this emerging discipline.

An accessible guide to the main reasons pumps fail—and what can be done about it Workhorses in many different industries, including the oil industry, water industry, chemical industry, food industry, and pharmaceutical industry to name a few, pumps are a vital contributor to maintaining and increasing the flow of production. In fact, the pump industry itself is a multi-billion dollar global business. Taking the unique approach of addressing both pump operators and pump designers, Pump Wisdom explains the causes of failure in centrifugal pump function—whether it's pump selection, overlooked installation criteria, or the accumulation of small deviations—and maps out remedies with well defined methods that target specific issues, rather than focusing on technical generalities and theory. Clearly written and concise, Pump Wisdom relies on proven tactics for reducing pump vulnerabilities and correcting imbalances between hydraulic assembly and mechanical assembly. In addition, it supplies sound tips for detecting and rectifying risky shortcuts taken by pump designers and manufacturers. Pump Wisdom also: Provides a concise explanation of how pumps function Details the specifications to be considered when purchasing a pump Provides tips on the installation of centrifugal pumps in process plants Written in concise language that avoids excessive mathematical treatment Explains pump hydraulics in easy to understand terms Emphasizes the mechanical aspects of pumps with coverage on bearings, seals, impeller trimming, lubricant application, lubricant types, and more Pump Wisdom sheds light on the techniques for stabilizing pump performance and maximizing pump efficiency. Its concise format allows readers to strike directly at the heart of the problem—and helps them devise strategies to prevent costly failures before they occur.

Distance protection provides the basis for network protection in transmission systems and meshed distribution systems. This book covers the fundamentals of distance protection and the special features of numerical technology. The emphasis is placed on the application of numerical distance relays in distribution and transmission systems. This book is aimed at students and engineers who wish to familiarise themselves with the subject of power system protection, as well as the experienced user, entering the area of numerical distance protection. Furthermore it serves as a reference guide for solving application problems. For this fourth edition all contents, especially the descriptions of numerical protection devices and the very useful appendix have been revised and updated.

Edited and authored by top international experts, this first book on conjugated polymers with a focus on synthesis provides a detailed overview of all modern synthetic methods for these highly interesting compounds. As such, it describes every important compound class, including polysilanes, organoboron compounds, and ferrocene-containing conjugated polymers. An indispensable source for every synthetic polymer chemist.

The go-to guide for learning what to say and how to say it In this climate of near constant streams of media messages, organizations need to know how to effectively communicate risks to their audiences and what to say when a crisis strikes. Risk and Crisis Communications: Methods and Messages is designed to help organizations understand the essential components of communicating about risks during a crisis, and it carves out a role for safety health and environmental (SH&E) professionals in the process. Covering common theoretical concepts and explaining the positions of noted experts in the field such as Peter Sandman and Vincent Covello, the book provides a fundamental understanding of the process behind crafting effective messages for a variety of different situations and explains the consequences of saying the wrong thing to an emotional audience. Incorporating numerous case studies—including the BP Deepwater Horizon Oil Spill and the 2010 H1N1 pandemic—it shows how messages can change the way an audience perceives an event and how they react to it, clearly demonstrating how ineffective messages can create untold difficulties for an organization's public image. Savvy SH&E professionals know that their role in helping to craft risk and crisis messages as well as assisting in the execution of risk communication plans provides a critical path to becoming more valuable members of their organizations. Risk and Crisis Communications: Methods and Messages provides invaluable assistance in helping SH&E professionals add value to their organization.

Presenting cutting-edge research and development within multiscale modeling techniques and frameworks, Multiscale Analysis of Deformation and Failure of Materials systematically describes the background, principles and methods within this exciting new & interdisciplinary field. The author’s approach emphasizes the principles and methods of atomistic simulation and its transition to the nano and sub-micron scale of a continuum, which is technically important for nanotechnology and biotechnology. He also pays close attention to multiscale analysis across the micro/meso/macroscopy of a continuum, which has a broad scope of applications encompassing different disciplines and practices, and is an essential extension of mesomechanics. Of equal interest to engineers, scientists, academics and students, Multiscale Analysis of Deformation and Failure of Materials is a multidisciplinary text relevant to those working in the areas of materials science, solid and computational mechanics, bioengineering and biomaterials, and aerospace, automotive, civil, and environmental engineering. Provides a deep understanding of multiscale analysis and its implementation Shows in detail how multiscale models can be developed from practical problems and how to use the multiscale methods and software to carry out simulations Discusses two interlinked categories of multiscale analysis; analysis spanning from the atomistic to the micro-continuum scales, and analysis across the micro/meso/macro scale of continuum.

Many books on sustainability have been written in the last decade, most of them dealing with agricultural systems, communities, and general business practices. In contrast, Handbook of Sustainability for the Food Sciences presents the concept of sustainability as it applies to the food supply chain from farm to fork but with a special emphasis on processing. Structured in four sections, Handbook of Sustainability for the Food Sciences first covers the basic concepts of environmental sustainability and provides a detailed account of all the impacts of the food supply chain. Part two introduces the management principles of sustainability and the tools required to evaluate the environmental impacts of products and services as well as environmental claims and declarations. Part three looks at ways to alleviate food chain environmental impacts and includes chapters on air emissions, water and wastewater, solid waste, energy, packaging, and transportation. The final part summarizes the concepts presented in the book and looks at the measures that will be required in the near future to guarantee long term sustainability of the food supply chain. Handbook of Sustainability for the Food Sciences is aimed at food science professionals including food engineers, food scientists, product developers, managers, educators, and decision makers. It will also be of interest to students of food science.

This book serves as a training tool for individuals in industry and academia involved with heat transfer applications. Although the literature is inundated with texts emphasizing theory and theoretical derivations, the goal of this book is to present the subject of heat transfer from a strictly pragmatic point of view. The book is divided into four Parts: Introduction, Principles, Equipment Design Procedures and Applications, and ABET-related Topics. The first Part provides a series of chapters concerned with introductory topics that are required when solving most engineering problems, including those in heat transfer. The second Part of the book is concerned with heat transfer principles. Topics that receive treatment include Steady-state Heat Conduction, Unsteady-state Heat Conduction, Forced Convection, Free Convection, Radiation, Boiling and Condensation, and Cryogenics. Part three (considered the heart of the book) addresses heat transfer equipment design procedures and applications. In addition to providing a detailed treatment of the various types of heat exchangers, this part also examines the impact of entropy calculations on exchanger design, and operation, maintenance and inspection (OM&I), plus refractory and insulation effects. The concluding Part of the text examines ABET (Accreditation Board for Engineering and Technology) related topics of concern, including economies and finance, numerical methods, open-ended problems, ethics, environmental management, and safety and accident management.

This book provides methods to train process operators to solve challenging problems. The book is split into two parts. The first part consists of two parts; first developing a daily monitoring system and second providing a structured 5 step problem solving approach that combines cause and effect problem solving thinking with the formulation of theoretically correct hypotheses. The 5 step approach emphasizes the classical problem solving approach (defining the sequence of events) with the addition of the steps of formulating a theoretically correct working hypothesis, providing a means to test the hypothesis, and providing a foolproof means to eliminate the problem. The initial part of the book focuses on defining the problem that must be solved and obtaining the location, time and quantity based specifications of the problem. This part of the book also presents techniques to find and define problems at an early point before they progress to the critical level. The second part of the book deals with the utilization of fundamental chemical engineering skills to develop a technically correct working hypothesis that is the key to successful problem solving. The primary emphasis is on simple pragmatic calculation techniques that are theoretically correct. It is believed that any operator can perform these calculations if he is provided the correct prototype. Throughout the book, the theory behind each pragmatic calculation technique is explained in understandable terms prior to presenting the author's approach. These techniques have been developed by the author in 50+ years of industrial experience. The book includes many sample problems and examples of real world problem solving. Using these techniques, theoretically correct working hypotheses can be developed in an expedient fashion.

This book describes the principles of image and video compression techniques and introduces current and popular compression standards, such as the MPEG series. Derivations of relevant compression algorithms are developed in an easy-to-follow fashion. Numerous examples are provided in each chapter to illustrate the concepts.

Dr Donald Bailey starts with introductory material considering the problem of embedded image processing, and how some of the issues may be solved using parallel hardware solutions. Field programmable gate arrays (FPGAs) are introduced as a technology that provides flexible, fine-grained hardware that can readily exploit parallelism within many image processing algorithms. A brief review of FPGA programming languages provides the link between a software mindset normally associated with image processing algorithms, and the hardware mindset required for efficient utilization of a parallel hardware design. The design process for implementing an image processing algorithm on an FPGA is compared with that for a conventional software implementation, with the key differences highlighted. Particular attention is given to the techniques for mapping an algorithm onto an FPGA implementation, considering timing, memory bandwidth and resource constraints, and efficient hardware computational techniques. Extensive coverage is given of a range of low and intermediate level image processing operations, discussing efficient implementations and how these may vary according to the application. The techniques are illustrated with several example applications or case studies from projects or applications he has been involved with. Issues such as interfacing between the FPGA and peripheral devices are covered briefly, as is designing the system in such a way that it can be more readily debugged and tuned. Provides a bridge between algorithms and hardware Demonstrates how to avoid many of the potential pitfalls Offers practical recommendations and solutions Illustrates several real-world applications and case studies Allows those with software backgrounds to understand efficient hardware implementation Design for Embedded Image Processing on FPGAs is ideal for researchers and engineers in the vision or image processing industry, who are looking at smart sensors, machine vision, and robotic vision, as well as FPGA developers and application engineers. The book can also be used by graduate students studying imaging systems, computer engineering, digital design, circuit design, or computer science. It can also be used as supplementary text for courses in advanced digital design, algorithm and hardware implementation, and digital signal processing and applications. Companion website for the book: www.wiley.com/go/bailey/fpga