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This book provides an overview of excipients, their functionalities in pharmaceutical dosage forms, regulation, and selection for pharmaceutical products formulation. It includes development, characterization methodology, applications, and up-to-date advances through the perspectives of excipients developers, users, and regulatory experts. Covers the sources, characterization, and harmonization of excipients: essential information for optimal excipients selection in pharmaceutical development Describes the physico-chemical properties and biological effects of excipients Discusses chemical classes, safety and toxicity, and formulation Addresses recent efforts in the standardization and harmonization of excipients

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

Advances in Equine Upper Respiratory Surgery is a comprehensive, up-to-date reference on surgical techniques in the upper respiratory tract in the horse, presenting theory and background as well as detailed procedures information. Part of the Advances in Veterinary Surgery series copublished with the ACVS Foundation, the book covers the most common upper respiratory diseases, with in-depth information on laryngeal hemiplegia and dorsal displacement of the soft palate. Providing a complete resource, the book reflects the current state of the art, offering a significant update on disorders of the nasal septum, nasal passage, paranasal sinuses, hard and soft palate, epiglottis, arytenoids, guttural pouch, and trachea in the horse. The book includes 200 images illustrating key points of each surgical procedure. Potential complications and expectation management are discussed alongside the technique information. Advances in Equine Upper Respiratory Surgery is a useful reference for those in clinical practice and surgical residents.

Focused Ultrasound Techniques for the Small Animal Practitioner offers a highly practical guide to incorporating abbreviated ultrasound exams into the veterinary practice. Focused point-of-care exams are an effective way to quickly detect conditions and complications not readily apparent through the physical exam, laboratory diagnostics, or radiographic findings. Encompassing all the information needed to begin performing these techniques, Focused Ultrasound Techniques for the Small Animal Practitioner is a useful tool for improving patient outcomes in clinical practice. Covering focused exams in all body systems, the book also outlines the principles of interventional radiology, medical documentation, and the basic fundamentals of using an ultrasound machine. A companion website offers 87 video clips of AFAST, TFAST, and Vet Blue examinations with normal, abnormal, and incidental findings at www.wiley.com/go/lisciandro/ultrasound. Focused Ultrasound Techniques for the Small Animal Practitioner is an essential purchase for veterinary practitioners and specialists wanting to implement these techniques in their veterinary practice.

Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Small Animal Dentistry, Second Edition presents essential information in a succinct, well-defined format for easy and quick access. This fully revised edition offers more color images, general updates from recent developments, and extensive revisions to the diagnostic and techniques sections, as well as additional information on charting with corresponding illustrations. New topics include exotic pets, including ferrets, prairie dogs, and chinchillas; oral pain management; home care; the technician in dentistry; and the business of dentistry. Topics cover diagnostics and treatment in a logical step-wise fashion, taking the typical Five-Minute format. Ancillary subjects on pain management, home care, and small mammal care have also been addressed and expanded, and a new companion website offers client education handouts to download and use in practice at www.wiley.com/go/lobprise. Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Small Animal Dentistry is the ideal practical manual for general practitioners seeking accessible, reliable information on dentistry techniques and treatments.

Advances in the Canine Cranial Cruciate Ligament, Second Edition presents in-depth, focused, and updated coverage of current knowledge on cruciate ligament rupture, using a multidisciplinary, evidence-based approach. Presents a state-of-the-art summary of the most recent knowledge on this important cause of lameness in dogs Led by a highly respected surgeon and researcher, with chapters written by leading experts in the field Provides an update to the groundbreaking first edition, with six new chapters

Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Small Animal Emergency and Critical Care, Second Edition provides essential information about treating medical emergencies using a quick-reference format ideal for the fast-paced emergency setting. Offers fast access to important information during a small animal emergency Presents topics alphabetically with identically formatted topics for ease of use Adds information on 25 new diseases and updates throughout, plus updated references and more information on drugs available outside the US Features color photographs to depict the diseases and conditions discussed Includes access to a companion website with client education handouts to download and use in practice

Currently more than 100,000 patients undergo blood and marrow transplantation (BMT) annually worldwide, a number which is steadily increasing. Long-term survival after BMT has improved significantly since its inception over 40 years ago, due to improved supportive care and early recognition of long-term complications. With broadening indications, more options for BMT, and improvement in survival, by 2020 there may be up to a million long-term survivors after BMT globally. Higher than average rates of second malignancies and cardiopulmonary, infectious, endocrine, and renal diseases, and bone loss or avascular necrosis amongst this population suggest that the rapidly swelling ranks of BMT survivors require more frequent screening and earlier interventions than the general population. The purpose of Blood and Marrow Transplantation Long-Term Management is to describe practical approaches to screening for and managing these late effects, with the goal of reducing preventable morbidity and mortality associated with BMT. This unique new book is the first to address the needs of the increasing population of long-term survivors after stem cell transplantation, making it a must-have resource for all oncologists, hematologists, and primary care physicians involved in the long-term management and care of BMT patients. Titles of related interest Thomas’ Hematopoietic Cell Transplantation, 4th edition Appelbaum, ISBN 9781405153485 Practical Stem Cell Transplantation Cant, ISBN 9781405134019 Mollison’s Blood Transfusion in Clinical Medicine, 12th edition Klein, ISBN 9781405199407

Previous edition won First Prize in the Gastroenterology category of the 2008 BMA Medical Book Competition High-resolution endoscopy and narrowband imaging have revolutionized the field. Edited by a gastroenterologist with a reputation for delivering outstanding material, this new edition of an award-winning atlas provides you with an outstanding collection of images, videos, and expert diagnostic guidance to enhance your decision making. To accelerate your learning, Dr. Cohen offers more than 2000 endoscopic images, emphasizing conditions for which NBI is particularly useful – such as finding dysplasia in Barrett's mucosa, and diagnosing adenomatous colon polyps – and providing exceptional preparation for the future of endoscopy practice, with a broad new look at normal and abnormal findings throughout the GI tract. The book is divided into three main parts: The basics of NBI Clinical applications of NBI Atlas of 1600 color images, broken into sections on the pharynx and esophagus, stomach, small intestine, and colon, including correlating histopathology and multiple examples of key pathologies The accompanying website features more than 85 video clips containing over 3 hours of annotated video, to give you a complete sense of how HRE and NBI work and look in real time, including during therapeutic procedures. All of the over 1000 new images appear in much brighter color, reflecting the advance in scope technology since the first edition. New chapters have been added to present the data supporting increased use of NBI in optical diagnosis and in the context of therapeutic procedures. For the first time, brilliant images of the bile duct and pancreas are included as the imaging revolution has expanded to reach these new locations. This spectacular new imaging modality promises to enhance endoscopic decision making in real time, facilitate therapeutic maneuvers, make tissue sampling more precise, and make resection of mucosal neoplasia more complete. Expertly guiding you through the latest advances, this book facilitates your mastery of the field, and provides an up-to-date reference for gastroenterologists and endoscopists to improve their practice.

Confidently devise a safe and successful ‘plan for the pump run’ for patients undergoing surgery for congenital heart disease. This practical guide for perfusionists and other members of the cardiac surgical team provides information on the devices, technology and techniques required for successful bypass of patients with congenital heart defects A practical, spiral-bound, go-to reference designed to answer the most frequently-posed questions about bypass for CHD, the surgical treatment of which is often complicated Focuses on the latest technology and techniques and provides clear, matter-of-fact guidance based on specific diagnoses Written by a seasoned perfusionist who is co-chief and educator at one of the world’s leading children’s hospitals Spiral binding allows the book to be laid flat for easy referral in the operating room A notes section following each diagnosis enables readers to add institution and/or surgeon-specific information to tailor a bypass plan for each CHD lesion

Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspe

Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise particularly in the last two decades. Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brainstimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activity dependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation. Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians.