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Written and edited by today's most-recognized inteventional cardiology thought leaders, this popular guide focuses on key procedures and techniques. Each strategic or tactical move is graded by complexity level and described in a simple, step-by-step approach that includes guidance on how to overcome practical difficulties and navigate particularly challenging clinical scenarios and complications. It offers interventional cardiologists, fellows in interventional cardiology, cath lab nurses and technicians; vascular surgeons and fellows, interventional radiologists: «Tips and tricks» gathered from the personal experience of over fifty international experts Clear, practical, step-by-step guidance on the latest procedures and techniques, performing challenging interventions, and managing complications and other difficult situations where evidence may be limited or inconsistent New coverage of hot topics such as percutaneous aortic valve replacement, renal artery ablation, intracranial interventions, and more

Exposing a developing embryo or fetus to alcohol can produce life long brain damage with neurological, cognitive and behavioural consequences. The implications of fetal alcohol spectrum disorder for the affected individual and the family are devastating. The social and economic burden to society is enormous with formidable expenditures in health care, mental health care, education, social services and possibly correctional services. Prevention has been a goal since the condition was medically described and defined forty years ago, but has remained elusive but feasible. This book reviews the evidence for effective strategies. It lays out what needs to be done. The book should be of great value to policy makers, clinicians, researchers and others advocating for action against this condition that is reducing the potential of our society and sapping its resources.

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.

In psychiatry, as in all of medicine, clinicians are frequently involved in training students and residents yet few have themselves been trained in pedagogy. Improving the quality of psychiatric education should both improve the quality of psychiatric care and make the profession more attractive to medical students. Written by a team of international experts with many years of experience, this comprehensive text takes a globally relevant perspective on providing practical instruction and advice on all aspects of teaching psychiatry. It covers learning from undergraduate and postgraduate level to primary medical and community settings, enabling readers to find solutions to the problems they are facing and become aware of potential issues which they can anticipate and be prepared to address. The book discusses curriculum development using examples from around the world, in order to provide trainees with the basic attitudes, knowledge and skills they require to practise psychiatry. Features: Instruction on developing a curriculum for Residency training, teaching interviewing skills, teaching psychotherapy and using new technology Innovative ways of engaging medical students in psychiatry and developing their interest in the specialty, including experience with new types of elective and research options and development of roles for students in patient care Focuses throughout on how to teach rather than what to teach Includes descriptions of workplace-based assessments Discussions of both theoretical and practical perspectives and examples of particular innovations in the field using case studies Presented in a thoroughly readable and accessible manner, this book is a primary resource for all clinicians involved in teaching psychiatry to medical students and trainees.

The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically-relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published. Confidently apply gold standard treatment for 10 of the most critical areas of cardiology Written by an international team of experts, Cardiovascular Clinical Trials: Putting the Evidence into Practice: Provides a succinct overview of recent major clinical trials – the gold standard for all medical treatment – across all the major cardiovascular subspecialties, to ensure you’re up-to-date on the most critical findings Guides cardiology trainees and clinicians on how cardiovascular clinical trials are designed and conducted, including statistical methodology, so you can conduct and/or appraise future trials yourself Addresses methodology as well as clinical effectiveness Offers evidence-based assessments on the most effective treatments and authoritative clinical information on management of the conditions so you can confidently apply what you learn Physicians, surgeons, specialist nurses – any clinician seeking an accessible resource for designing and conducting cardiovascular trials and then translating their results into practice will appreciate this book’s clear guidance and succinct and practical approach.

Like the ground-breaking first edition, Pediatric Psycho-oncology, Second edition puts the child at the centre of medical and psychological care. It broadens the focus beyond treatment and cure to consider the quality of life of the child and their family. Written by an international group of pediatric oncologists and psychologists/psycho-oncologists brought together by an expert editorial team, it focuses on the real-life practical aspects of children undergoing treatment for cancer. This edition has been restructured and opens with a major section on Active treatment, which includes chapters addressing quality of life, pain, psychosocial aspects of treatment and interventions, art therapy and different fantasy-based techniques, palliative care, communication and education, as well as a new chapter on psychopharmacology. Shorter sections then discuss survivorship and care of the dying child, including a new chapter on bereavement. The final section comprises new chapters on ethical considerations and on addressing the emotional needs of children whose parents have cancer, as well as a case study on international collaboration. An appendix provides a comprehensive overview of tools for evaluation and assessment in pediatric psychooncology. This book is a highly practical resource that will be invaluable for all health care professionals looking after children and adolescents with cancer.

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to «real» screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real «how to» book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.

The first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world’s leading authorities in abdominal imaging, Richard C. Semelka MD. User-friendly, atlas-style presentation, with over 1500 MRI and CT images in over 320 figures featuring state-of-the-art MR and CT imaging sequences, multidetector row CT images, 3D reformatted images, breath-hold MRI sequences, and cutting-edge MR 3T images Highly practical approach for imaging of focal and diffuse liver lesions, complete relevant and systematic (differential) diagnostic information, the latest references to primary literature and clinical evidence, and patient management possibilities Reflects a pattern-recognition approach to MRI and CT imaging, assisting with efficient scanning of images and assessment and diagnosis of disorders

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.