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The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) – the ultimate online resource for NMR and MRI. Up to now MRI could not be used clinically for imaging fine structures of bones or muscles. Since the late 1990s however, the scene has changed dramatically. In particular, Graeme Bydder and his many collaborators have demonstrated the possibility – and importance – of imaging structures in the body that were previously regarded as being “MR Invisible”. The images obtained with a variety of these newly developed methods exhibit complex contrast, resulting in a new quality of images for a wide range of new applications. This Handbook is designed to enable the radiology community to begin their assessment of how best to exploit these new capabilities. It is organised in four major sections – the first of which, after an Introduction, deals with the basic science underlying the rest of the contents of the Handbook. The second, larger, section describes the techniques which are used in recovering the short T2 and T2* data from which the images are reconstructed. The third and fourth sections present a range of applications of the methods described earlier. The third section deals with pre-clinical uses and studies, while the final section describes a range of clinical applications. It is this last section that will surely have the biggest impact on the development in the next few years as the huge promise of Short T2 and T2* Imaging will be exploited to the benefit of patients. In many instances, the authors of an article are the only research group who have published on the topic they describe. This demonstrates that this Handbook presents a range of methods and applications with a huge potential for future developments. About EMR Handbooks / eMagRes Handbooks The Encyclopedia of Magnetic Resonance (up to 2012) and eMagRes (from 2013 onward) publish a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of EMR Handbooks / eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of articles from eMagRes. In consultation with the eMagRes Editorial Board, the EMR Handbooks / eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written (together with updates of some already existing articles) to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes Vie

This book covers the developmental and health problems unique to the adolescent period of life. It focuses on special needs and public health programs for adolescents. It offers deep insight into smoking, violence, teen pregnancy, HIV/AIDS, and other problems, along with intervention and prevention strategies. «Anyone serious about improving adolescent health should read this book. It spans theoretical and developmental constructs, summaries of evidence-based interventions for adolescent risk behaviors, metrics, and policy recommendations.» —S. Jean Emans, MD, chief, Division of Adolescent Medicine, and Robert Masland Jr., chair, Adolescent Medicine, Children's Hospital Boston, and professor of pediatrics, Harvard Medical School «This is the one single text that students can use to study adolescent health. It includes contributions from many of the world's most accomplished researchers to provide learners with cutting edge information to make the study of adolescence understandable and applicable in practical settings.» —Gary L. Hopkins, MD, DrPH, associate research professor and director, Center for Prevention Research, and director, Center for Media Impact Research, Andrews University «This textbook presents an excellent balance in weighing the evidence from the risk and the resilience literature, incorporating research in racially and ethnically diverse populations.» —Renée R. Jenkins, MD, FAAP, professor, Department of Pediatrics and Child Health, Howard University College of Medicine "This is an engaging, thorough, and thought-provoking statement of our knowledge about adolescence. " —Wendy Baldwin, PhD, director, Poverty, Gender, and Youth Program, Population Council

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

This unique book will help psychiatrists to understand better the risks of cardiovascular illness and cardiologists to appreciate possible pathophysiological links with psychiatric conditions. It describes the common psychiatric conditions, their key features and how they may influence cardiovascular disease, outcomes, and quality of life. It also considers the cardiovascular complications that may arise as a result of mental illness. In an exciting, collaborative approach, psychiatrists and cardiologists combine their expertise throughout the book to provide guidance on the best way to manage such patients, considering the patient as a whole, not the individual conditions.

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Depressive disorders have profound social and economic consequences, owing to the suffering and disability they cause. They often occur together with somatic illness which worsens the prognosis of both. Prevention, detection and optimal treatment of these disorders are therefore of great clinical and economic importance. This edition of the first title in the acclaimed Evidence & Experience series from the World Psychiatric Association has been fully revised and features a new section on depression in primary care – the main channel for the management of these disorders in countries around the world. The format remains a systematic review of each topic, evaluating published evidence, complemented by up to six commentaries in which experts provide valuable insight gained from clinical experience. All the evidence, systematically reviewed and analysed, in one place. Practical context imparted in expert commentaries from around the world, which were highly popular in the previous edition. Provides an unbiased and reliable reference source for practising psychiatrists and physicians everywhere. Features a new section on the treatment of depression in primary care. Edited by a highly experienced, internationally renowned team. This book will be informative and stimulating reading for everyone working with people with depressive disorders in all countries and settings: psychiatrists, psychologists, primary care physicians and other mental healthcare professionals. Review of the first edition “The discussion papers are excellent. I strongly recommend this masterfully edited book, which remarkably succeeds in combining research evidence and clinical experience. It is probably the most helpful update on depression available today, both for the researcher in mood disorders and the practising clinician.” S. Grandi in Psychotherapy and Psychosomatics, 2000

Evidence-Based Orthodontics satisfies the educational demands of orthodontics, which demands the integration of the best research evidence with the clinician’s expertise and the patient’s unique values and circumstances. This land-mark text is the first to be devoted to the methodology, principles and practice of evidence-based practice in orthodontics. It aims to serve as a reference for those wishing to understand the principles of evidence-based practice including the foundation for clinical study design, epidemiology and the statistical inferences from data. The ability to define a search strategy from established databases and to identify relevant clinical and translational research in the scientific published literature requires a new approach in orthodontic education. Evidence-Based Orthodontics provides a contemporary approach to those strategies in clinical orthodontic practice. The growing ability to translate critical appraisals of evidence into clinical practice and evaluate clinical evidence for its validity and potential usefulness requires an understanding of basic elements in epidemiology and biostatistics. Evidence-Based Orthodontics provides its readers with a cogent, clear resource with which to navigate and understand this important subject area. It provides students and practitioners of orthodontics with an indispensible guide to this vital tenet of education, research, and clinical practice.

Recently, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. Patients with psychiatric problems, particularly depression, may be more susceptible to cardiovascular disorders. Depression and Heart Disease synthesizes current evidence, including some previously unpublished data, in a concise, easy-to-read format. The authors succinctly describe the epidemiology, pathogenesis (including cytokines and genetics), and risk factors of the comorbidity between depression and heart disease. The book also reviews the best pharmacological and psychotherapeutic approaches for people with this comorbidity.

Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.

This volume presents a fresh international perspective on current approaches to treating heart failure. An accessible reference for hospital-based specialists, the book provides an update on recent advances in therapeutics and pharmacology, as well as ongoing trials. Four major sections concentrate on a review of screening, assessment and diagnosis; an update on drug treatments; an update on device therapy; and a description of best practice recommendations for managing clinically challenging cases

Clinical Research in Oral Health surveys the essentials of clinical research in oral health, anchoring these principles within the specific context of the oral health arena. Addressing research questions exclusively applicable to dentistry and oral health, the book thoroughly illustrates the principles and practice of oral health clinical research. Clinical Research in Oral Health also clarifies the framework of regulatory issues and presents emerging concepts in clinical translation, relating the research principles to clinical improvement.

Praise for the First Edition « . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students.»—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.