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A comprehensive guide to optimizing the lifecycle management of pharmaceutical brands The mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand drugs essential for pharmaceutical companies looking to maximize the value of their products. Demonstrating how different measures can be combined to create winning strategies, Pharmaceutical Lifecycle Management: Making the Most of Each and Every Brand explores this increasingly important field to help readers understand what they can—and must—do to get the most out of their brands. Offering a truly immersive introduction to LCM options for pharmaceuticals, the book incorporates numerous real-life case studies that demonstrate successful and failed lifecycle management initiatives, explaining the key takeaway of each example. Filled with practical information on the process of actually writing and presenting an LCM plan, as well as how to link corporate, portfolio, and individual brand strategies, the book also offers a look ahead to predict which LCM strategies will continue to be effective in the future. While the development of new drugs designed to address unmet patient needs remains the single most important goal of any pharmaceutical company, effective LCM is invaluable for getting the greatest possible value from existing brands. Pharmaceutical Lifecycle Management walks you through the process step by step, making it indispensable reading for pharmaceutical executives and managers, as well as anyone working in the fields of drug research, development, and regulation.

The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns. Edited by the internationally acclaimed founders of the philosophy and social movement of transhumanism, The Transhumanist Reader is an indispensable guide to our current state of knowledge of the quest to expand the frontiers of human nature.

Here are 101* of the best ideas to make the most effective use of your time on the ward. Over 250 contributors, including students, doctors, nurses, pharmacists, and therapists from 18 countries, help make you the finest doctor you can be! Pocket-sized for 'dipping into' during a spare moment or a couple of hours on the ward, this short guide is ideal for medical students on rotation or junior doctors who wish to boost learning and motivation. *There are actually 100 ideas. Now it's your turn to develop tip 101! Submit your ideas to www.101things.org

Initial Management of Acute Medical Patients is a clinically focused, practical and contemporary guide for assessing and managing patients with acute medical conditions. Suitable for all nurses and healthcare practitioners in medical assessment units and medical wards, as well as A&E staff, it uses a structured approach based on common presenting features and focuses on the first 24 hours of the patient's hospital stay. It draws on a wide range of supporting evidence and also provides sources for further reading. Key features: Written predominantly by nurses for nurses, this text is also suitable for a range of healthcare professionals, including paramedics and nurse practitioners, and anybody working in an acute care environment, including primary care assessment units, clinical decision units and intermediate care Designed as a quick reference text for use in clinical practice Extensively referenced throughout, thus increasing its appeal to practitioners at all stages of their careers and to those who are undertaking further study Devotes two entire chapters to assessing and meeting the acute care needs of vulnerable adults (i.e. older adults, those with mental health needs, and those with learning disabilities), and discussing best practice in dealing with sudden death Each chapter offers clear, concise and down-to-earth information based on a common presenting symptom and provides practical advice, supported by best evidence and the most up to date clinical guidelines Fully updated and extensively expanded to include recent guidelines and procedures

A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.

Understanding Children and Young People's Mental Health has been designed to help the student and newly qualified health care professional to familiarise themselves with the key theoretical frameworks underpinning the field of children and young people's mental health. It explores the mental health challenges that children and young people face, and how we as adults can work alongside them to help them face and overcome such challenges. This book provides comprehensive information on the theory and practice of particular mental health difficulties which children and young people may have to face, including self-harm, depression, suicide, child abuse, eating disorders, substance misuse, and early onset psychosis. Understanding Children and Young People's Mental Health is essential reading for pre-registration students in nursing and healthcare on child and mental health branches, and for newly qualified nursing, health and social care practitioners who work with children and young people. Brings together specialist practitioners and academics in the field Incorporates the latest guidelines and policies Practical and accessible in style with learning outcomes, activities, examples and recommended reading in each chapter

Rheumatology Practice in Occupational Therapy: Promoting Lifestyle Management is a valuable new handbook focusing on rheumatology, a core area of occupational therapy practice. It provides practical guidance to help occupational therapists treat and manage rheumatic conditions in both clinical and community settings and emphasises a contemporary ‘client-centred’ approach as a fundamental requirement of effective and rewarding occupational therapy practice. Drawing upon personal, clinical and theoretical perspectives, Rheumatology Practice in Occupational Therapy equips the reader with an understanding of the relevant practical skills and of the clinical reasoning required to modify and apply these skills to the needs of individual people. Written by experts from occupational therapy, sociology and psychology, this book addresses the need to adapt occupational therapy interventions to each client’s own experience of living with a rheumatic condition and develops the reader’s understanding of key theoretical and clinical approaches to person-centred management. Rheumatology Practice in Occupational Therapy is essential reading for all occupational therapists helping people with rheumatic conditions in hospital and community settings, and for students preparing for practice. It will also be of interest to other healthcare professionals working with people with these conditions. • Includes personal narratives of people trying to live their lives within the context of a debilitating condition • Promotes understanding of key theoretical and clinical approaches to person-centred management • Written by authors with extensive experience in clinical and research contexts • Offers practical resource sections at the end of each chapter Related titles Occupational Therapy and Older People, 2nd Edition Anita Atwal, Anne McIntyre 978-1-4443-3333-6 Role Emerging Occupational Therapy: Maximising Occupation Focused Practice Miranda Thew, Mary Edwards, Sue Baptiste, Matthew Molineux 978-1-4051-9782-3 Interprofessional Rehabilitation: A Person-Centred Approach Sarah G. Dean, Richard J. Siegert, William J. Taylor 978-0-470-65596-2

The latest addition to the Evidence-Based Book series, Evidence-Based Geriatric Medicine provides non-geriatrician clinicians an overview of key topics central to the care of the older patient. This guide focuses on the management of common problems in the elderly taking into account their life situations as well as treatment of specific conditions. Leading geriatricians with expertise in evidence-based medicine utilize the best available evidence and present this information in a concise, easy-to-use, question-based format. Evidence-Based Geriatric Medicine is a unique guide to the optimum management of older patients.

As the fastest growing population sector worldwide, older adults are seen in almost every care setting in which clinicians practice. Developed as a resource for advanced practice nurses in any setting, Case Studies in Gerontological Nursing for the Advanced Practice Nurse presents readers with a range of both typical and atypical cases from real clinical scenarios. The book is organized into six units covering cases related to ageism, common health challenges, health promotion, environments of care, cognitive and psychological issues, and issues relating to aging and independence. Each case follows a similar format including the patient's presentation, critical thinking questions, and a thorough discussion of the case resolution through which students and clinicians can enhance their clinical reasoning skills. Designed to promote geriatric clinical education through self-assessment or classroom use, Case Studies in Gerontological Nursing for the Advanced Practice Nurse is a key resource for all those dedicated to improving care for older adults.

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.

A comprehensive look at the latest research findings and clinical applications of oncogenic viruses Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen. Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book. Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.

This book is a very welcome tool, which will enable health professionals to understand the complexity, challenge and rewards of proactively managing long-term conditions. Putting this knowledge into skilled practice, in partnership with patients, will transform the lives of many individuals and their families, and thus fulfil the fundamental purpose of nursing. —From the Foreword by Professor Rosemary Cook CBE, Director, the Queen’s Nursing Institute and Visiting Professor of Enterprise, University of Northumbria Long-Term Conditions is a comprehensive, practical guide for nurses and healthcare professionals on the care and management of people with chronic illness. It explores case management, individual care and management, the role of the ‘expert patient’, quality-of-life issues, counselling skills, self-management, and optimum self-care. Long-Term Conditions discusses the three main long-term conditions currently resulting in most hospital admissions: diabetes, respiratory, and coronary heart disease, with a focus on empowering the patient to self-manage. Key Features: A comprehensive guide to the care and management of long-term conditions Focuses on the management of the conditions from the patients’ perspective Practical and accessible in style