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This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

This ready reference discusses different methods for statistically analyzing and validating data created with high-throughput methods. As opposed to other titles, this book focusses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network. From a methodological point of view, the well balanced contributions describe a variety of modern supervised and unsupervised statistical methods applied to various large-scale datasets from genomics and genetics experiments. Furthermore, since the availability of sufficient computer power in recent years has shifted attention from parametric to nonparametric methods, the methods presented here make use of such computer-intensive approaches as Bootstrap, Markov Chain Monte Carlo or general resampling methods. Finally, due to the large amount of information available in public databases, a chapter on Bayesian methods is included, which also provides a systematic means to integrate this information. A welcome guide for mathematicians and the medical and basic research communities.

Open-Bite Malocclusion: Treatment and Stability presents the etiology, treatment, and its stability of anterior open bite malocclusion in the early, mixed, and permanent dentitions. Special emphasis is devoted to orthodontic treatment and its stability in the permanent dentition because this is the time when treatment of open bite presents greater relapse. Appropriate for clinicians, orthodontic residents, and dental students, Open-Bite Malocclusion covers the most simple treatment approaches to the most complex, from orthodontic devices to tooth extraction to surgery. Unique to this book is the discussion of post-treatment stability. Drs. Janson and Valarelli highlight the post-treatment changes and presents strategies to increase treatment stability. This allows the clinician to be able to predict the stability probabilities when treating anterior open bite malocclusions in the permanent dentition either with or without extraction, orthodontic-surgical therapy, or with occlusal adjustment.

Responding to the growing interest in public health, Public Health Foundations is an accessible and comprehensive text that offers a reader-friendly introduction to core concepts and current practices. The authors use an engaging approach to topics such as epidemiology and pharmacoepidemiology, biostatistics, infectious disease, environmental health, social and behavioral sciences, health services and policy, quantitative and qualitative research methods, and health disparities. Ready for the classroom, each chapter includes learning objectives, an overview, detailed explanations, case studies, a summary, key terms, and review questions. Sidebars connect students to topics of current interest in the field of public health, including ethics, emerging and reemerging infectious diseases, environmental hazards, climate change, social justice, and issues of insurance and access to health care. Reflecting and expanding on recommendations of the Association of American Colleges and Universities, Public Health Foundations provides a solid framework for understanding the basics of public health and is the ideal text for a wide range of courses in public health. Companion Web site: josseybass.com/go/andresen

Rehearse for life in clinical practice with this easy-to-use and unique series, which combines cases drawn from real-life experiences with a refreshing approach to presentations as you would see them in day-to-day situations. Get the most from clinical practice, with Clinical Cases Uncovered This essential title in the Clinical Cases Uncovered series includes many important scenarios in respiratory medicine that feature in real-life clinical practice. Everything is covered, from respiratory arrest and asthma to environmental effects and abnormal chest X-rays. Anatomy, physiology and the relevant pathological background feature in the basic science section, with important advice on the approach to the patient. The self-assessment section at the end is crucial to testing your understanding, giving you the best possible preparation. For further information, visit www.clinicalcasesuncovered.com

This book provides its readers with a structured approach to decision-making and case management in oral rehabilitation. It is built around actual patient cases from simple prosthodontics to complex full-mouth reconstructions, demonstrating a formal process by which a diagnosis and treatment plan is reached. Grounded firmly in evidence-based principles, the book also includes a chapter on literature searching in dentistry, which is critical for acquiring a knowledge-base for informed decisions in clinical treatment. Featuring an approach to prosthodontics and oral rehabilitation that is both instructional and practical, Oral Rehabilitation: A Case-Based Approach will help clinicians to develop the necessary skills to make consistent, evidence-based clinical decisions. KEY FEATURES • Presents a case-based process showing how diagnosis and treatment is achieved • Covers a range of clinical scenarios from simple to complex presentations • Illustrates each case fully, with stages documented by colour photographs • Emphasises inter-disciplinary management in prosthodontics • Accompanied by a website containing illustrative video clips

Acute urinary stones cause one of the most painful sensations the human body can experience, more painful than childbirth, broken bones, gunshot wounds or burns. Master your patient management with this comprehensive guide to a debilitating medical condition. Urinary Stones: Medical and Surgical Management provides urologists, nephrologists and surgeons with a practical, accessible guide to the diagnosis, treatment and prevention of urinary stone disease. Divided into 2 parts – covering both medical and surgical management – leading experts discuss the key issues and examine how to deliver best practice in the clinical care of your patients. Topics covered include: Evaluation and management of stones in children Renal colic and medical expulsive therapy Imaging in stone disease: sonography, contrast based fluoroscopy, computed tomography and magnetic resonance urography Multimodality therapy: mixing and matching techniques to improve outcome Complications of stone disease Interpretation of 24 hour urine chemistry Prevention of recurrent calcium, uric acid, struvite and cystine stones The different surgical techniques, including: ureteroscopy, shockwave lithotripsy, ureteroscopic lithotripsy and percutaneous nephrostolithotomy Packed with high-quality figures, key points, and management algorithms, easy to follow, clear clinical guidance is supported by the very latest in management guidelines from the AUA and EAU. Brought to you by the best, this is the perfect consultation tool when on the wards or in the office.

A considerable number of journal publications using a range of qualitative synthesis approaches has been published. Mary Dixon-Woods and colleagues (Mary Dixon-Woods, Booth, & Sutton, 2007) identified 42 qualitative evidence synthesis papers published in health care literature between 1990 and 2004. An ongoing update by Hannes and Macaitis (2010)identified around 100 additional qualitative or mixed methods syntheses. Yet these generally lack a clear, detailed description of what was done and why (Greenhalgh et al, 2007; McInnes & Wimpenny, 2008). Choices are most commonly influenced by what others have successfully used in the past or by a particular school of thought (Atkins et al, 2008; Britten et al, 2002). This is a substantive limitation. This book brings balance to the options available to researchers, including approaches that have not had a substantial uptake among researchers. It provides arguments for when and why researchers or other parties of interest should opt for a certain approach to synthesis, which challenges they might face in adopting it and what the potential strengths and weaknesses are compared with other approaches. This book acts as a resource for readers who would otherwise have to piece together the methodology from a range of journal articles. In addition, it should stimulate further development and documentation of synthesis methodology in a field that is characterized by diversity.

Rehearse for life in clinical practice with this easy-to-use and unique series, which combines cases drawn from real-life experiences with a refreshing approach to presentations as you would see them in day-to-day situations. Get the most from clinical practice, with Clinical Cases Uncovered Packed full with over 120 cases, this comprehensive title on the surgical management of conditions will be your core revision text. Featuring everything you need to know on surgery, Professor Harold Ellis and Christopher Watson have left nothing out. Whether it's a gastric ulcer or an intercranial mass shown up on an MR scan, you can work your way through with Clinical Cases Uncovered. For further information, visit www.clinicalcasesuncovered.com

Gute Daten + gute Statistik = gute Ergebnisse! Mit diesem Buch haben falsche Statistiken keine Chance mehr. Übersichtlich gegliedert in 6 Teile mit zusammen 20 Kapiteln werden hier alle wichtigen Typen von Daten und die Verfahren zu deren Auswertung erklärt. Die erklärte Maxime des Autors ist es, dass sich eine statistische Auswertung immer an der Art und Qualität der Daten orientieren muss, damit diese nicht fehl- oder überinterpretiert werden. Komplizierte Mathematik ist dabei weder nötig noch erwünscht, denn meistens sind die einfachsten Verfahren die aussagekräftigsten. Ein positiver Lerneffekt stellt sich bereits nach wenigen Seiten ein, denn hier werden genau die Fragen gestellt (und beantwortet!), mit denen ein angehender Mediziner oder Pharmazeut während der Ausbildung konfrontiert wird. Mit seinem ungezwungenen und direkten Stil gelingt es dem Autor, dass die Statistik vom ungeliebten Kind zum effizienten Werkzeug wird, auch ohne mathematische Begabung beim Leser. * Leicht verständliche Texte (fast) ohne Formeln * Alle Beispiele kommen aus der Medizin oder der Pharmazie * Warnhinweise auf häufi ge Fehler und auf den unsachgemäßen Einsatz von Statistiken Als leicht verständliche Einführung in die statistischen Grundlagen und Verfahren, die in der Medizin und in der Pharmazie eingesetzt werden, ist dieses Buch bestens geeignet für alle, die eine Ausbildung im medizinischpharmazeutischen Bereich absolvieren.

Assisted reproduction techniques have led to the birth of 4 million babies worldwide Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges. Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient. Written by 122 internationally renowned experts, Assisted Reproduction Techniques follows the patient's journey throughout the whole ART process, with chapters on: Counseling and preparation Ovarian stimulation Oocyte retrieval Embryo transfer The luteal phase The ART laboratory The male patient The ART pregnancy Each of the 100 concise chapters includes clinical cases, background, evidence-based practical management options, preventive measures and key-point summaries of the important details. Assisted Reproduction Techniques gives a wide-ranging practical guide to all those wishing to support couples who cannot conceive naturally.

Chest X-rays for Medical Students is a unique teaching and learning resource that offers students, junior doctors, trainee radiologists, nurses, physiotherapists and nurse practitioners a basic understanding of the principles of chest radiology. Provides a memorable way to analyze and present chest radiographs – the unique ‘ABCDE’ system as developed by the authors Explains how to recognize basic radiological signs, pathology and patterns associated with common medical conditions as seen on plain PA and AP chest radiographs Presents each radiograph twice, side by side – once as would be seen in a clinical setting and again with the pathology clearly highlighted Includes a section of self-assessment and presentation exercises to test knowledge and presentation technique Ideal for study and clinical reference, this book will be the ideal companion for any medical student, junior doctor or trainee radiographer.