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The fifth edition of Bojar's Manual of Perioperative Care in Adult Cardiac Surgery remains the gold standard for management of adult patients undergoing cardiac surgery. The easily referenced outline format allows health practitioners of all levels to understand and apply basic concepts to patient care–perfect for cardiothoracic and general surgery residents, physician assistants, nurse practitioners, cardiologists, medical students, and critical care nurses involved in the care of both routine and complex cardiac surgery patients. This comprehensive guide features: Detailed presentation addressing all aspects of perioperative care for adult cardiac surgery patients Outline format allowing quick access to information Chronological approach to patient care starting with diagnostic tests then covering preoperative, intraoperative, and postoperative care issues Additional chapters discuss bleeding, the respiratory, cardiac, and renal subsystems as well as aspects of care specific to recovery on the postoperative floor Updated references, information on new drug indications and new evidence to support various treatment/management options. Practical and accessible, this new edition of Manual of Perioperative Care in Adult Cardiac Surgery is the essential reference guide to cardiac surgical patient care.

Aimed at specialists in respiratory medicine, this new book comprehensively reviews the variety of agents currently available for treatment of asthma, COPD, and other airway diseases and covers practical guidelines as well as challenges and complications in their use. Advances in Combination Therapy for Asthma and COPD is the first book to address the complexity of multi-agent therapy and deal with management issues in an integrated fashion. A review of currently available agents and their applications, as well as new therapies soon to become available are outlined. Advantages of combined therapies and additional considerations that arise from multi-agent programs are highlighted.

Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests. Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation. Success Probability Estimation with Applications to Clinical Trials: • Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries Features practical solutions for problems that are often encountered in clinical trials Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.

Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.

Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.

It is quite common in a randomized clinical trial (RCT) to encounter patients who do not comply with their assigned treatment. Since noncompliance often occurs non-randomly, the commonly-used approaches, including both the as-treated (AT) and as-protocol (AP) analysis, and the intent-to-treat (ITT) (or as-randomized) analysis, are all well known to possibly produce a biased inference of the treatment efficacy. This book provides a systematic and organized approach to analyzing data for RCTs with noncompliance under the most frequently-encountered situations. These include parallel sampling, stratified sampling, cluster sampling, parallel sampling with subsequent missing outcomes, and a series of dependent Bernoulli sampling for repeated measurements. The author provides a comprehensive approach by using contingency tables to illustrate the latent probability structure of observed data. Using real-life examples, computer-simulated data and exercises in each chapter, the book illustrates the underlying theory in an accessible, and easy to understand way. Key features: Consort-flow diagrams and numerical examples are used to illustrate the bias of commonly used approaches, such as, AT analysis, AP analysis and ITT analysis for a RCT with noncompliance. Real-life examples are used throughout the book to explain the practical usefulness of test procedures and estimators. Each chapter is self-contained, allowing the book to be used as a reference source. Includes SAS programs which can be easily modified in calculating the required sample size. Biostatisticians, clinicians, researchers and data analysts working in pharmaceutical industries will benefit from this book. This text can also be used as supplemental material for a course focusing on clinical statistics or experimental trials in epidemiology, psychology and sociology.

This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code

Management of Pregnant and Neonatal Dogs, Cats, and Exotic Pets is a comprehensive yet practical reference on small animal neonatology. Covering reproductive physiology of pregnancy and parturition, normal neonatology, and neonatal disorders in dogs, cats, and small exotic mammals, the book gives special emphasis to fetal well-being, parturition, normal physical parameters, behavior, common disorders and defects, emergency care, and orphan management. Information on nutritional and environmental considerations for both the dam and offspring is included, as well as guidance on offering advice to breeders providing neonatal care at home. Well illustrated throughout, Management of Pregnant and Neonatal Dogs, Cats, and Exotic Pets is a complete resource for the successful management of pregnant and newborn pets. Veterinary practitioners, students, technicians, and professional breeders all will find the book’s how-to, clinically relevant approach to small animal neonatology invaluable.

The work of French Philosopher Luce Irigaray has exerted a profound influence on feminist thinking of recent decades and provides a far-reaching challenge to western philosophy's entrenched patriarchal norms. This book guides the reader through Irigaray's critical and creative transformation of western thought. Through detailed analysis of her most important text, Speculum of the Other Woman, Rachel Jones carefully examines Irigaray's transformative readings of such icons of the western tradition as Plato, Descartes, Kant and Hegel. She shows that these readings underpin Irigaray's claim that western philosophy has been dependent on the forgetting of both sexual difference and of our singular beginnings in birth. In response, Irigaray seeks to recover a positive account of sexual difference which would release woman from her traditional position as the 'other' of the subject and allow her to speak as a subject in her own right. In a sensitive reading of Irigaray's work, Jones shows why this distinctively feminist project necessarily involves the transformation of the fundamental terms of western metaphysics. By foregrounding Irigaray's approach to questions of otherness and alterity, she concludes that, for Irigaray, cultivating an ethics of sexuate difference is the condition of ethical relations in general. Lucidly and persuasively written, this book will be an invaluable resource for students and scholars seeking to understand Irigaray's original contribution to philosophical and feminist thought.

Clinical Small Animal Care: Promoting Patient Health through Preventative Nursing is an introduction to the principles of day-to-day veterinary practice, with coverage ranging from the initial assessment, fluid therapy monitoring, and perioperative management to care of animals with specific diseases. The book offers concrete guidance on best practices for promoting patient health in veterinary care, emphasizing specific techniques to prevent complications before they happen. A practical, clinically relevant resource for veterinary technicians, Clinical Small Animal Care provides step-by-step descriptions of the core tasks associated with examining, nursing, and monitoring small animal patients. Taking a hands-on approach to the fundamentals of clinical practice, the book gives specific advice for how to perform tasks associated with patient care. Chapters begin with basic information on topics such as husbandry and nutrition, then move into more specialized information on applied nursing and the care of tubes and catheters. The final section presents information on caring for animals with a variety of conditions organized by body system. Clinical Small Animal Care: Promoting Patient Health through Preventative Nursing offers veterinary technicians and nurses with achievable steps for improving health in their small animal patients.

The use of neurovascular ultrasound is of increasing importance in neurological practice, both for radiologists and increasingly by neurologists themselves. Written by the world’s most renowned expert, this book explains ultrasound examination of a stroke patient scanning protocols interpretation of the results Case examples (with a standard template presentation correlating presentation to waveform output) reinforce the book's practical nature. Illustrated with photos of the tests, explanations, and with actual waveforms, images, and result interpretation, and enhanced with 'pearls' and 'avoiding pitfalls' features, it is a practical reference for those learning ultrasound as well as those using ultrasound in their practices.

Wiley-Blackwell's «Clinical Cases» series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Periodontics describes the core principles of periodontics and demonstrates their practical, every-day application through a range of representative cases building from the simple to the complex and from the common to the rare. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from infant oral health to complex pulp therapy. Highly illustrated in full color, Clinical Cases in Periodontics utilizes a format that fosters independent learning and prepares the reader for case-based examinations. The book presents actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in periodontics. The book begins with a set of cases illustrating the most common diagnoses and the key decisions and evaluations leading up to them. Subsequent chapters continue in this style, presenting exemplary cases as the basis of discussing various treatment options including surgical and non-surgical treatment, regenerative therapy, mucogingival therapy, and interdisciplinary treatments. Concluding chapters cover implant site development and general prevention of such periodontal diseases. Clinical Cases in Periodontics's case-based format is particularly useful for pre-doctoral dental students, post-graduate residents and practitioners, both as a textbook from which to learn about the challenging and absorbing nature of periodontology, and also as a reference tool to help with treatment planning when complex cases present in the dental office.