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Children today are growing up in an increasingly commercialised world. But should we see them as victims of manipulative marketing, or as competent participants in consumer culture? The Material Child provides a comprehensive critical overview of debates about children’s changing engagement with the commercial market. It moves from broad overviews of the theory and history of children’s consumption to insightful case studies of key areas such as obesity, sexualisation, children’s broadcasting and education. In the process, it challenges much of the received wisdom about the effects of advertising and marketing, arguing for a more balanced account that locates children’s consumption within a broader analysis of social relationships, for example within the family and the peer group. While refuting the popular view of children as incompetent and vulnerable consumers that is adopted by many campaigners, it also rejects the easy celebration of consumption as an expression of children’s power and autonomy. Written by one of the leading international scholars in the field, The Material Child will be of interest to students, researchers and policy-makers, as well as parents, teachers and others who work directly with children.

The book provides a comprehensive compilation of fundamentals, technical solutions and applications for medical imaging systems. It is intended as a handbook for students in biomedical engineering, for medical physicists, and for engineers working on medical technologies, as well as for lecturers at universities and engineering schools. For qualified personnel at hospitals, and physicians working with these instruments it serves as a basic source of information. This also applies for service engineers and marketing specialists. The book starts with the representation of the physical basics of image processing, implying some knowledge of Fourier transforms. After that, experienced authors describe technical solutions and applications for imaging systems in medical diagnostics. The applications comprise the fields of X-ray diagnostics, computed tomography, nuclear medical diagnostics, magnetic resonance imaging, sonography, molecular imaging and hybrid systems. Considering the increasing importance of software based solutions, emphasis is also laid on the imaging software platform and hospital information systems.

Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Every year throughout the world, individuals’ health is damaged by their exposure to toxic chemicals at work. In most cases these problems will resolve, but many will sustain permanent damage. Whilst any justified claim for compensation requires medical and legal evidence a crucial and often controversial component of this process is the establishment of a causal link between the individual’s condition and exposure to a specific chemical or substance. Causation, in terms of how a substance or substances led the claimant to his or her current plight, can be difficult to establish and the main purpose of this book, is to provide the aspiring expert report writer with a concise, practical guide that uses case histories to illuminate the process of establishing causation in occupational toxicity proceedings. In summary: A practical, accessible guide to the preparation of balanced, scientifically sound expert reports in the context of occupational toxicology. Focuses on the scientist’s role in establishing a causal link between exposure to toxins and an individual’s ill health. Includes real-life case histories drawn from the Author’s 15 years experience in this area to illustrate the principles involved. Expert Report Writing in Toxicology: Forensic, Scientific and Legal Aspects proves invaluable to scientists across a range of disciplines needing guidance as to what is expected of them in terms of the best use of their expertise and how to present their findings in a manner that is authoritative, balanced and informative.

This book guides the reader through FDA regulation guidelines and outlines a comprehensive strategy for cost reduction in regulatory affairs and compliance. This book explains six strategies to cost-effectively comply with FDA regulations while maintaining product safety and improving public access through cost controls. It provides useful and practical guidance through industry case studies from pharmaceutical, biotech, and medical device industries.

This book provides an essential understanding of statistical concepts necessary for the analysis of genomic and proteomic data using computational techniques. The author presents both basic and advanced topics, focusing on those that are relevant to the computational analysis of large data sets in biology. Chapters begin with a description of a statistical concept and a current example from biomedical research, followed by more detailed presentation, discussion of limitations, and problems. The book starts with an introduction to probability and statistics for genome-wide data, and moves into topics such as clustering, classification, multi-dimensional visualization, experimental design, statistical resampling, and statistical network analysis. Clearly explains the use of bioinformatics tools in life sciences research without requiring an advanced background in math/statistics Enables biomedical and life sciences researchers to successfully evaluate the validity of their results and make inferences Enables statistical and quantitative researchers to rapidly learn novel statistical concepts and techniques appropriate for large biological data analysis Carefully revisits frequently used statistical approaches and highlights their limitations in large biological data analysis Offers programming examples and datasets Includes chapter problem sets, a glossary, a list of statistical notations, and appendices with references to background mathematical and technical material Features supplementary materials, including datasets, links, and a statistical package available online Statistical Bioinformatics is an ideal textbook for students in medicine, life sciences, and bioengineering, aimed at researchers who utilize computational tools for the analysis of genomic, proteomic, and many other emerging high-throughput molecular data. It may also serve as a rapid introduction to the bioinformatics science for statistical and computational students and audiences who have not experienced such analysis tasks before.

The facts about Lyme disease, from epidemiology to treatment to control Lyme borreliosis, popularly known as Lyme disease, remains the most commonly reported tick-transmitted infection in North America and Europe. A growing body of scientific and clinical evidence has facilitated early diagnosis and effective treatment. Nonetheless, there are a number of misconceptions about this infectious disease that have given rise to unproven, potentially dangerous alternative therapies. In Lyme Borreliosis in Europe and North America, a team of authors whose expertise spans basic research, epidemiology, and clinical practice has compiled evidence-based information on Lyme borreliosis. Presents all the latest evidence needed to diagnose, treat, and prevent Lyme disease Lyme Borreliosis in Europe and North America begins with a review of the disease's epidemiology, the causative Borrelia genospecies, and tick vectors. It then explores pathogenesis, diagnosis, and treatment. Next, the book examines the role of serologic, culture, and molecular diagnostic methods. The book also features a chapter on prognosis, offering an evidence-based review of outcome studies, as well as practical advice to physicians to help them manage the challenging clinical scenario of chronic symptoms attributed to Borrelia infection. The final chapter is a guide to prevention strategies, including the management of tick bites. Examines similarities and differences in Europe and North America Because differences in Borrelia genospecies are responsible for differences in the clinical presentation of Lyme borreliosis between North America and Europe, this book provides descriptions of the disease as it presents on each continent. Most of the chapters have been cowritten by experts on each continent, in order to provide a balanced perspective that combines European and North American findings, practices, and experiences. Helps everyone better understand, treat, and control Lyme disease Lyme Borreliosis in Europe and North America is a comprehensive reference, ideal for clinicians, researchers, and public health officials who seek to treat and control Lyme borreliosis. It will help them better understand the facts and make sense of the misconceptions and myths that surround this infectious disease.

Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer: Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.

Depression in Neurologic Disorders Diagnosis and Management Edited by Andres M. Kanner, MD, Professor of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA. Why should neurologists care about depression? It is one of the most frequent psychiatric comorbid conditions of neurologic disorders. Not only does it have a negative impact on the quality of patients, but it is also associated with a worse course of the neurologic disease. Yet, more often than not, neurologists have not been trained to recognize clinical depression in their patients. How should neurologists learn to care for depression? By reading Depression in Neurologic Disorders, the caring neurologist will gain a practical overview of: clinical manifestations of depression in the major neurologic disorders how to use screening instruments in clinical practice the identification of patients with an increased suicidal risk basic principles of the management of depressive disorders by the non-psychiatrist The major neurologic disorders covered in Depression in Neurologic Disorders include: Migraine Stroke Epilepsy Parkinson’s Disease Multiple Sclerosis Huntington’s Disease Dementia Traumatic Brain Injury The practical approach is enhanced with the use of case studies and ‘take-home pearls’ throughout. Depression is a common disorder that all neurologists face in their daily clinical practice. Depression in Neurologic Disorders provides the fundamentals of caring for patients who are suffering beyond their diagnosed neurologic disorder. Titles of Related Interest Adult Epilepsy Gregory Cascino and Joseph Sirven (eds); ISBN 978-0-470-74122-1 Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment Alberto Albanese and Joseph Jankovic (eds); 978-0-470-74122-1 Multiple Sclerosis: Diagnosis and Therapy Howard Weiner and James Stankiewicz; 978-0-470-65463-7

This book will be an affordable, highly practical handbook on hepatology, aimed at residents/trainees in gastroenterology, GI nurses, and recently qualified consultants to use as a quick reference when managing patients presenting with possible or overt liver disease. It will be of particular use for those GI internists/residents who have an interest specifically in hepatology. It does not aim to be a specialist textbook, but a shorter, 250pp guide that provides key clinical information on each area of hepatology in an accessible form. Extracting relevant material from large reference textbooks can be very time consuming and for this reason, information in this handbook will be presented succinctly in a style suitable for quick reference and easy understanding. The chief emphasis will be on the clinical assessment and management of these patients, and all the major areas of liver disease will be covered, from liver cirrhosis to viral hepatitis, to autoimmune liver failure. Chapters will use a variety of structural features and colour coded boxes to increase the accessibility for residents. These include: key points/take-home points, case history, practice points and management algorithm/flow-charts. Each chapter will also contain sample multiple choice questions that the reader will be able to test themselves on.

This book bridges the gap between practitioners of supply-chain management and pharmaceutical industry experts. It aims to help both these groups understand the different worlds they live in and how to jointly contribute to meaningful improvements in supply-chains within the globally important pharmaceutical sector. Scientific and technical staff must work closely with supply-chain practitioners and other relevant parties to help secure responsive, cost effective and risk mitigated supply chains to compete on a world stage. This should not wait until a drug has been registered, but should start as early as possible in the development process and before registration or clinical trials. The author suggests that CMC (chemistry manufacturing controls) drug development must reset the line of sight – from supply of drug to the clinic and gaining a registration, to the building of a patient value stream. Capable processes and suppliers, streamlined logistics, flexible plant and equipment, shorter cycle times, effective flow of information and reduced waste. All these factors can and should be addressed at the CMC development stage.

Obsessive compulsive disorder (OCD) remains one of the most challenging disorders of the brain. Contemporary conceptualization and therapeutic strategies are undergoing a revolution as a result of new insights derived from modern technological advances. This book was conceived in order to present this revolution to the reader. It covers current theories regarding the etiology of OCD, what is known about the genetics of this disorder, evidence from neuroimaging and a discussion of potential endophenotypes. There is an evaluation of current treatment approaches for the disorder, encompassing psychological, psychopharmacological and physical interventions, as well as a discussion of treatment resistance. The book considers methodological issues, plus reviews of OCD in pediatric populations. A summary chapter highlights some potential research avenues, in a discussion of the future directions in OCD. Rather than provide comprehensive coverage, repeating material from standard psychiatry textbooks, this book focuses on recent information and its application, distinguishing it from other titles. If you work in children with OCD, If you are interested in genetics, neurocognition or brain imaging, If you work with patients and would like to improve your assessment in OCD and OCD Spectrum disorders, to update your therapeutic strategies and to get a handle on cutting edge developments in this intriguing field, If you are planning a research project in OCD and would like to get some hints from people who are research leaders in this field and also learn about methodological issues specific to OCD research, then this book will be a valuable resource. A concise overview of the current state of the art in OCD assessment and treatment, including physical interventions and treatment resistance Focuses on scientific advances (including specific methodological issues) and how they can inform and benefit clinical practice Looks critically and broadly at the diagnostic classification, including the ongoing revision of the two major international systems Written by an A-list team of experts in the field who have a track record of being engaging authors