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The Sixth Edition of Adams and Stashak’s Lameness in Horses builds on the book’s reputation as the classic gold-standard reference on equine lameness. Now in full color, the text has been fully revised and streamlined to improve user-friendliness, with a new, simplified format and a stronger emphasis on the diagnosis and management of lameness. A valuable supplementary DVD provides a complete guide to diagnosing lameness, offering additional anatomical images; video clips demonstrating key procedures such as physical examination, flexion tests, perineural and intrasynovial anesthesia; and examples of lameness conditions in motion. The Sixth Edition presents new or significantly rewritten chapters on the axial skeleton, principles of musculoskeletal disease, principles of therapy for lameness, occupation-related lameness conditions, and lameness in the young horse. The diagnostic procedures chapter has also been significantly expanded to reflect advances in this important area. Adams and Stashak’s Lameness in Horses, Sixth Edition is an essential addition to any equine practitioner’s bookshelf.

This text is an accessible, student-friendly introduction to the wide range of mathematical and statistical tools needed by the forensic scientist in the analysis, interpretation and presentation of experimental measurements. From a basis of high school mathematics, the book develops essential quantitative analysis techniques within the context of a broad range of forensic applications. This clearly structured text focuses on developing core mathematical skills together with an understanding of the calculations associated with the analysis of experimental work, including an emphasis on the use of graphs and the evaluation of uncertainties. Through a broad study of probability and statistics, the reader is led ultimately to the use of Bayesian approaches to the evaluation of evidence within the court. In every section, forensic applications such as ballistics trajectories, post-mortem cooling, aspects of forensic pharmacokinetics, the matching of glass evidence, the formation of bloodstains and the interpretation of DNA profiles are discussed and examples of calculations are worked through. In every chapter there are numerous self-assessment problems to aid student learning. Its broad scope and forensically focused coverage make this book an essential text for students embarking on any degree course in forensic science or forensic analysis, as well as an invaluable reference for post-graduate students and forensic professionals. Key features: Offers a unique mix of mathematics and statistics topics, specifically tailored to a forensic science undergraduate degree. All topics illustrated with examples from the forensic science discipline. Written in an accessible, student-friendly way to engage interest and enhance learning and confidence. Assumes only a basic high-school level prior mathematical knowledge.

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Leitfaden der DFG wie vor allem Nachwuchsforscher in diesem interdisziplinaren Gebiet in den Genuss von Fordermittel kommen.

Compatibility of Pharmaceutical Products and Contact Materials Dennis Jenke Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable and extractable chemicals associated with drug product packaging, manufacturing systems, and devices. The most comprehensive resource available, its coverage includes the strategies, tactics, and regulatory requirements for performing safety assessments, along with the means for interpreting results. Structured around a logical framework for an extractables and leachables safety assessment and closely linked to the pharmaceutical product development process, Compatibility of Pharmaceutical Products and Contact Materials directly addresses the fundamental questions of «what activities need to be performed to completely, efficiently, and effectively address the issue of product safety from an extractables and leachables perspective?» and «when do the various required activities need to be performed?» Specifically, the chapters describe: Pertinent regulations and practical ways to meet guidelines Coordinating manufacturing, storage, and delivery systems development and qualification with therapeutic product development Materials characterization and the materials screening process Component and/or system qualification (illustrated by several case studies) Performing validation/migration studies and interpreting and reporting the results Creating a product registration dossier and putting it through regulatory review Product maintenance (Change Control) from an extractables and leachables perspective Likely future developments in extractables and leachables assessment Additionally, the book's appendix provides a database, including CAS registry numbers, chemical formulas and molecular weights of extractable/leachable substances that have been reported in the chemical literature. Detailing the interconnected roles played by analytical chemistry, biological science, toxicology, and regulatory science, Compatibility of Pharmaceutical Products and Contact Materials supplies a much-needed, comprehensive resource to all those in pharmaceutical product or medical device development.

Microbiology of Drinking Water Production and Distribution addresses the public health aspects of drinking water treatment and distribution. It explains the different water treatment processes, such as pretreatment, coagulation, flocculation, sedimentation, filtration, disinfection, and their impacts on waterborne microbial pathogens and parasites. Drinking water quality may be degraded in water distribution systems—microorganisms form biofilms within distribution systems that allow them to flourish. Various methodologies have been proposed to assess the bacterial growth potential in water distribution systems. Microbiology of Drinking Water Production and Distribution also places drinking water quality and public health issues in context; it addresses the effect of bioterrorism on drinking water safety, particularly safeguards that are in place to protect consumers against the microbial agents involved. In addition, the text delves into research on drinking water quality in developing countries and the low-cost treatment technologies that could save lives. The text also examines the microbiological water quality of bottled water, often misunderstood by the public at large.

Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse

Medical students and junior and senior doctors are frequently called upon to give research presentations, write reports, and answer exam questions on specific areas of medical research. Understanding Medical Research: The Studies That Shaped Medicine is an exciting new title that offers a unique and valuable approach to understanding historically influential studies in important areas of medicine. Featuring chapters from Sir Liam Donaldson and Sir David Weatherall, amongst others, world leading researchers identify ten primary research papers that have shaped the direction of research in their given topic, examining why they were carried out, key findings, and how they changed the field. Each chapter also contains short sections on ‘Key Questions Remaining’ which outline outstanding areas where further research is needed, and a link to ‘Key Laboratories/Clinics’ which point the reader to major research groups of international standing. Covering the seminal research in core areas of medicine, Understanding Medical Research provides an authoritative framework on each topic for medical students and healthcare professionals.

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Concepts in Male Health Concepts in Male Health: Perspectives Across the Lifespan offers a practical approach to understanding the health of males of all races, ethnicities, socioeconomic status, cultures, ages, and orientations. Each chapter of this book comprehensively reviews an important dimension of male health and examines the contributing historical, epidemiological,??psychosocial, cultural-ethical, legal, political, and economic influences. The diverse range of topics allows for complete coverage ranging from body structures??and sexuality to aggression and occupational health. ??The book contains the most recent research and evidence-based science and addresses issues in male health throughout the lifespan in an easy-to-understand format. ??Learning objectives are presented in an accessible format and reflect real life situations. Review questions provided at the end of each chapter address health-specific content included in the chapter and span both the scope and the breadth of the information. This book is ideal for programs in health education, public health, community health nursing, gender studies, and other health sciences.