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This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry

Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.

This book presents the most up-to-date and comprehensive guide to the current and potential future state of weed science and research. Weeds have a huge effect on the world by reducing crop yield and quality, delaying or interfering with harvesting, interfering with animal feeding (including poisoning), reducing animal health and preventing water flow. They are common across the world and cost billions of dollars’ worth of crop losses year on year, as well as billions of dollars in the annual expense of controlling them. An understanding of weeds is vital to their proper management and control, without which the reduction in crop yields that they would cause could lead to mass starvation across the globe. Topics covered include weed biology and ecology, control of weeds and particular issues faced in their control. Authored and edited by internationally renowned scientists in the field all of whom are actively involved in European Weed Research Society working groups, this succinct overview covers all the relevant aspects of the science of weeds. Weed Research: Expanding Horizons is the perfect resource for botanists, horticultural scientists, agronomists, weed scientists, plant protection specialists and agrochemical company personnel.

Clear, integrated coverage of all aspects of nonlinear optics—phenomena, materials, and devices Coauthored by George Stegeman, one of the most highly respected pioneers of nonlinear optics—with contributions on applications from Robert Stegeman—this book covers nonlinear optics from a combined physics, optics, materials science, and devices perspective. It offers a thoroughly balanced treatment of concepts, nonlinear materials, practical aspects of nonlinear devices, and current application areas. Beginning with the presentation of a simple electron on a spring model—to help readers make the leap from concepts to applications—Nonlinear Optics gives comprehensive explanations of second-order phenomena, derivation of nonlinear susceptibilities, third-order nonlinear effects, multi-wave mixing, scattering, and more. Coverage includes: Nonlinear response of materials at the molecular level Second-order nonlinear devices, their optimization and limitations The physical origins of second- and third-order nonlinearities Typical frequency dispersion of nonlinearities, explained in terms of simple two- and three-level models Ultrafast and ultrahigh intensity processes Practice problems demonstrating the design of such nonlinear devices as frequency doublers and optical oscillators Based on more than twenty years of lectures at the College of Optics and Photonics (CREOL) at the University of Central Florida, Nonlinear Optics introduces all topics from the ground up, making the material easily accessible not only for physicists, but also for chemists and materials scientists, as well as professionals in diverse areas of optics, from laser physics to electrical engineering.

Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Deep-water (below wave base) processes, although generally hidden from view, shape the sedimentary record of more than 65% of the Earth’s surface, including large parts of ancient mountain belts. This book aims to inform advanced-level undergraduate and postgraduate students, and professional Earth scientists with interests in physical oceanography and hydrocarbon exploration and production, about many of the important physical aspects of deep-water (mainly deep-marine) systems. The authors consider transport and deposition in the deep sea, trace-fossil assemblages, and facies stacking patterns as an archive of the underlying controls on deposit architecture (e.g., seismicity, climate change, autocyclicity). Topics include modern and ancient deep-water sedimentary environments, tectonic settings, and how basinal and extra-basinal processes generate the typical characteristics of basin slopes, submarine canyons, contourite mounds and drifts, submarine fans, basin floors and abyssal plains.

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

A multidisciplinary overview of bio-derived solvent applications, life cycle analysis, and strategies required for industrial commercialization This book provides the first and only comprehensive review of the state-of-the-science in bio-derived solvents. Drawing on their own pioneering work in the field, as well as an exhaustive survey of the world literature on the subject, the authors cover all the bases—from bio-derived solvent applications to life cycle analysis to strategies for industrial commercialization—for researchers and professional chemists working across a range of industries. In the increasingly critical area of sustainable chemistry, the search for new and better green solvents has become a top priority. Thanks to their renewability, biodegradability and low toxicity, as well as their potential to promote advantageous organic reactions, green solvents offer the promise of significantly reducing the pernicious effects of chemical processes on human health and the environment. Following an overview of the current solvents markets and the challenges and opportunities presented by bio-derived solvents, a series of dedicated chapters cover all significant classes of solvent arranged by origin and/or chemical structure. Throughout, real-world examples are used to help demonstrate the various advantages, drawbacks, and limitations of each class of solvent. Topics covered include: The commercial potential of various renewably sourced solvents, such as glycerol The various advantages and disadvantages of bio-derived versus petroleum-based solvents Renewably-sourced and waste-derived solvents in the design of eco-efficient processes Life cycle assessment and predictive methods for bio-based solvents Industrial and commercial viability of bio-based solvents now and in the years ahead Potential and limitations of methodologies involving bio-derived solvents New developments and emerging trends in the field and the shape of things to come Considering the vast potential for new and better products suggested by recent developments in this exciting field, Bio-Based Solvents will be a welcome resource among students and researchers in catalysis, organic synthesis, electrochemistry, and pharmaceuticals, as well as industrial chemists involved in manufacturing processes and formulation, and policy makers.

This book provides a comprehensive introduction to multiple-point geostatistics, where spatial continuity is described using training images. Multiple-point geostatistics aims at bridging the gap between physical modelling/realism and spatio-temporal stochastic modelling. The book provides an overview of this new field in three parts. Part I presents a conceptual comparison between traditional random function theory and stochastic modelling based on training images, where random function theory is not always used. Part II covers in detail various algorithms and methodologies starting from basic building blocks in statistical science and computer science. Concepts such as non-stationary and multi-variate modeling, consistency between data and model, the construction of training images and inverse modelling are treated. Part III covers three example application areas, namely, reservoir modelling, mineral resources modelling and climate model downscaling. This book will be an invaluable reference for students, researchers and practitioners of all areas of the Earth Sciences where forecasting based on spatio-temporal data is performed.

Examines the foundation of pulse power technology in detail to optimize the technology in modern engineering settings Pulsed power technologies could be an answer to many cutting-edge applications. The challenge is in how to develop this high-power/high-energy technology to fit current market demands of low-energy consuming applications. This book provides a comprehensive look at pulsed power technology and shows how it can be improved upon for the world of today and tomorrow. Foundations of Pulsed Power Technology focuses on the design and construction of the building blocks as well as their optimum assembly for synergetic high performance of the overall pulsed power system. Filled with numerous design examples throughout, the book offers chapter coverage on various subjects such as: Marx generators and Marx-like circuits; pulse transformers; pulse-forming lines; closing switches; opening switches; multi-gigawatt to multi-terawatt systems; energy storage in capacitor banks; electrical breakdown in gases; electrical breakdown in solids, liquids and vacuum; pulsed voltage and current measurements; electromagnetic interference and noise suppression; and EM topology for interference control. In addition, the book: Acts as a reference for practicing engineers as well as a teaching text Features relevant design equations derived from the fundamental concepts in a single reference Contains lucid presentations of the mechanisms of electrical breakdown in gaseous, liquid, solid and vacuum dielectrics Provides extensive illustrations and references Foundations of Pulsed Power Technology will be an invaluable companion for professionals working in the fields of relativistic electron beams, intense bursts of light and heavy ions, flash X-ray systems, pulsed high magnetic fields, ultra-wide band electromagnetics, nuclear electromagnetic pulse simulation, high density fusion plasma, and high energy- rate metal forming techniques.

This textbook provides an integral and integrated treatment of industrial-relevant problems for students of both chemistry and chemical engineering. As such, this work combines the four disciplines of chemical technology – chemistry, thermal and mechanical unit operations, chemical reaction engineering and general chemical technology – and is organized into two main parts. The first covers the fundamentals, as well as the analysis and design of industrial processes, while the second section presents 20 concrete processes, exemplifying the inherent applied nature of chemical technology. These are selected so that they all differ with respect to at least one important aspect, such as the type and design of the reactor, the chemistry involved or the separation process used. As a result, readers will recapitulate, deepen and exercise the chemical and engineering principles and their interplay, as well as being able to apply them to industrial practice. Instructive figures, rules of thumb for swift but reliable estimating of parameters, data of chemical media, and examples utilizing data from industrial processes facilitate and enhance the study process. A small general survey of selected modern trends, such as multifunctional and micro reactors, or new solvents for homogeneous catalysis, such as ionic liquids, point out to the reader that this is not a concluded discipline, but a developing field with many challenges waiting to be solved.

Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.