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This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

A comprehensive introduction to coastal storms and their associated impacts Coastal Storms offers students and professionals in the field a comprehensive overview and groundbreaking text that is specifically devoted to the analysis of coastal storms. Based on the most recent knowledge and contributions from leading researchers, the text examines coastal storms’ processes and characteristics, the main hazards (such as overwash, inundation and flooding, erosion, structures overtopping), and how to monitor and model storms. The authors include information on the most advanced innovations in forecasting, prediction, and early warning, which serves as a foundation for accurate risk evaluation and developing adequate coastal indicators and management options. In addition, structural overtopping and damage are explained, taking into account the involved hydrodynamic and morphodynamic processes. The monitoring methods of coastal storms are analyzed based on recent results from research projects in Europe and the United States. Methods for vulnerability and risk evaluation are detailed, storm impact indicators are suggested for different hazards and coastal management procedures analyzed. This important resource includes: Comprehensive coverage of storms and associated impacts, including meteorological coastal storm definitions and related potential consequences A state-of-the-art reference for advanced students, professionals and researchers in the field Chapters on monitoring methods of coastal storms, their prediction, early warning systems, and modeling of consequences Explorations of methods for vulnerability and risk evaluation and suggestions for storm impact indicators for different hazards and coastal management procedures Coastal Storms is a compilation of scientific and policy-related knowledge related to climate-related extreme events. The authors are internationally recognized experts and their work reflects the most recent science and policy advances in the field.

The formalism processing of unbuckled solids mechanics involves several mathematical tools which are to be mastered at the same time. This volume collects the main points which take place in the course of the formalism, so that the user immediately finds what he needs without looking for it. Furthermore, the book contains a methodological formulary to guide the user in his approach.

The set of books on Mechanical Engineering and Solid Mechanics, of which this book is the first volume, is an essential tool for those looking to develop a rigorous knowledge of the discipline, whether students, professionals (in search of an approach to a problem they are dealing with), or anyone else interested. This volume deals with the elements required for establishing the equations of motion when dealing with solid bodies. Chapter 1 focuses on the systems of reference used to locate solid bodies relative to the observer, and demonstrates how to describe their position, orientation, and evolution during their motion. Chapter 2 introduces descriptors of motion such as velocity and acceleration, and develops the concept of torsor notation in relation to these descriptors. Finally, Chapter 3 concerns the notions of mass and inertia, as well as the kinetic torsor and dynamic torsor which consolidate the kinematic and kinetic aspects in a single concept.

This volume is the focal point of the work undertaken in the previous volumes of this set of books: the statement of the fundamental principle of the dynamics whose implementation, according to two paths whose choice depends on the problem to be treated, leads to equations of motion. In order to achieve this, it is treated first of all in the context of solids in their environment, as a prerequisite for the formulation of the fundamental principle. Then, in addition to its use in some exercises, the approach is illustrated by three particular cases. The first is an example where it is developed end-to-end and addresses the two approaches that lead to the equations of motion. The two other examples deal with two classical but important subjects, the movement of the Earth according to the hypotheses that can be stated about it, and Foucault’s pendulum.

This book introduces the mathematical techniques for turbulence control in a form suitable for inclusion in an engineering degree program at both undergraduate and postgraduate levels whilst also making it useful to researchers and industrial users of the concepts. It uses a mix of theory, computation and experimental results to present and illustrate the methodologies. It is based on the three part structure, wall turbulence, open loop control and feedback control with emphasis on optimal control methodologies. The book also includes an introduction of basic principles and fundamentals followed by a chapter on the structure of wall turbulence with emphasis on coherent structures. Elsewhere there is focus on control methods of wall turbulence by manipulating the boundaries though their motion and by applying control forces throughout the flow volume. The last two chapters will describe the linear and non-linear optimal controls. This integrated approach will help not only researchers interested in the topic but also graduate or advanced undergraduate students in their course work.

This book investigates sand production problems in the development of unconsolidated sand reservoirs and suggests novel technical solutions and improvements to sand management issues. This book is divided into six chapters: (1) geologic characteristics of unconsolidated sand heavy oil reservoirs and concept of sand management technology; (2) sand production mechanisms and its effect on reservoir petrophysical quality; (3) sand production quantity prediction and well productivity evaluation methods, especially for fluid-solid coupling prediction model; (4) completion technology for sand management; (5) sand flow in well bore and surface processing; (6) the application of sand management technology in China’s Bohai heavy oil field. Readership: Petroleum reservoir engineers and production managers worldwide.

The second edition of the «go-to» reference in this field is completely updated and features more than 80% new content, with emphasis on new developments in the field, especially in industrial applications. No other book covers the topic in such a comprehensive manner and in such high quality. Edited by the Nobel laureate R. H. Grubbs and E. Khosravi, Volume 3 of the 3-volume work focusses on polymer synthesis. With a list of contributors that reads like a «Who's-Who» of metathesis, this is an indispensable one-stop reference for chemists in academia and industry. View the set here – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527334246.html Other available volumes: Volume 1: Catalyst Development and Mechanism, Editors: R. H. Grubbs and A. G. Wenzel – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html Volume 2: Applications in Organic Synthesis, Editors: R. H. Grubbs and D. J. O´Leary – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339493.html

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions – including key routes for synthesizing complex molecules. • Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses • Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions • Helps readers to design efficient and practical transformations using multicomponent reaction strategies • Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms

A wide-ranging, interdisciplinary exploration of key topics that interrelate pest management, public health and the environment This book takes a unique, multidimensional approach to addressing the complex issues surrounding pest management activities and their impacts on the environment and human health, and environmental effects on plant protection practices. It features contributions by a distinguished group of authors from ten countries, representing an array of disciplines. They include plant protection scientists and officers, economists, agronomists, ecologists, environmental and public health scientists and government policymakers. Over the course of eighteen chapters, those experts share their insights into and analyses of an array of issues of vital concern to everyone with a professional interest in this important subject. The adverse effects of pest control have become a subject of great concern worldwide, and researchers and enlightened policymakers have at last begun to appreciate the impact of environmental factors on our ability to manage pest populations. Moreover, while issues such as pesticide toxicity have dominated the global conversation about pest management, economic and societal considerations have been largely neglected. Environmental Pest Management: Challenges for Agronomists, Ecologists, Economists and Policymakers is the first work to provide in-depth coverage of all of these pressing issues between the covers of one book. Offers a unique multi-dimensional perspective on the complex issues surrounding pest management activities and their effect on the environment and human health Addresses growing concerns about specific pest management strategies, including the use of transgenic crops and biological controls Analyses the influence of global processes, such as climate change, biological invasions and shifts in consumer demand, and ecosystem services and disservices on pest suppression efforts Explores public health concerns regarding biodiversity, pesticide use and food safety Identifies key economic drivers of pest suppression research, strategies and technologies Proposes new regulatory approaches to create sustainable and viable crop protection systems in the framework of agro-environmental schemes Offering a timely and comprehensively-unique treatment of pest management and its environmental impacts in a single, inter-disciplinary volume, this book is a valuable resource for scientists in an array of disciplines, as well as government officials and policymakers. Also, teachers of undergraduate and graduate level courses in a variety of fields are sure to find it a highly useful teaching resource.

Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery