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Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.

This book presents the methodology and applications of a range of important topics in statistics, and is designed for graduate students in Statistics and Biostatistics and for medical researchers. Illustrations and more than ninety exercises with solutions are presented. They are constructed from the research findings of the medical journals, summary reports of the Centre for Disease Control (CDC) and the World Health Organization (WHO), and practical situations. The illustrations and exercises are related to topics such as immunization, obesity, hypertension, lipid levels, diet and exercise, harmful effects of smoking and air pollution, and the benefits of gluten free diet. This book can be recommended for a one or two semester graduate level course for students studying Statistics, Biostatistics, Epidemiology and Health Sciences. It will also be useful as a companion for medical researchers and research oriented physicians.

A step-by-step approach to problem-solving techniques using SPSS® in the fields of sports science and physical education Featuring a clear and accessible approach to the methods, processes, and statistical techniques used in sports science and physical education, Sports Research with Analytical Solution using SPSS® emphasizes how to conduct and interpret a range of statistical analysis using SPSS. The book also addresses issues faced by research scholars in these fields by providing analytical solutions to various research problems without reliance on mathematical rigor. Logically arranged to cover both fundamental and advanced concepts, the book presents standard univariate and complex multivariate statistical techniques used in sports research such as multiple regression analysis, discriminant analysis, cluster analysis, and factor analysis. The author focuses on the treatment of various parametric and nonparametric statistical tests, which are shown through the techniques and interpretations of the SPSS outputs that are generated for each analysis. Sports Research with Analytical Solution using SPSS® also features: Numerous examples and case studies to provide readers with practical applications of the analytical concepts and techniques Plentiful screen shots throughout to help demonstrate the implementation of SPSS outputs Illustrative studies with simulated realistic data to clarify the analytical techniques covered End-of-chapter short answer questions, multiple choice questions, assignments, and practice exercises to help build a better understanding of the presented concepts A companion website with associated SPSS data files and PowerPoint® presentations for each chapter Sports Research with Analytical Solution using SPSS® is an excellent textbook for upper-undergraduate, graduate, and PhD-level courses in research methods, kinesiology, sports science, medicine, nutrition, health education, and physical education. The book is also an ideal reference for researchers and professionals in the fields of sports research, sports science, physical education, and social sciences, as well as anyone interested in learning SPSS.

Shimizu's Dermatology, Second Edition provides practical, didactic, and rapid-reference advice on diagnosis and management of the most common dermatologic conditions. Written by one of the world's leading experts, and a best-seller in Japan where it was first published, the second edition is cohesive, richly illustrated, attractively presented, and fully revised to reflect the latest in clinical developments. This complete dermatology resource offers: Over 2,000 clinical images to aid rapid and easy diagnosis 100% clinically focused chapters describing the clinical features, classifications, pathogeneses, pathologies, treatments and lab findings of diseases Key points and tips and tricks in every chapter for practical guidance Attractive color presentation throughout, with high-quality clinical images Improve your knowledge of skin conditions and their management with this concise, user-friendly, alternative to larger reference books. Shimizu's Dermatology is ideal for specialists in clinical practice, trainees managing patients at clinics or hospitals or preparing for board exams, and medical students.

Benefit from this concise yet comprehensive manual, designed to improve the practice and process of STEMI interventions Understand the varied pharmacological options available in managing STEMI patients, including newer anti-coagulants Improve your STEMI procedure technique through expert guidance, including stent choice, and other techniques such as trans radial procedures Provides an overview of STEMI networks internationally and how to set up a STEMI program Reviews future perspectives for STEMI and the role of telemedicine for STEMI procedures

The only book dedicated to this important area of urology, Ureteric Stenting comprehensively reviews the entire topic, providing highly specialized advice to enable outstanding clinical management of patients. All aspects of ureteric stenting are covered, from basic to complex, giving urologists, nephrologists and trainees an authoritative and up-to-date guide on best clinical practice.

In the era of cost cutting and lack of adequate health insurance for many patients, clinical skills and time spent with patients are not adequately compensated. Yet, these dwindling and underpaid skills – good history taking, observation of and listening to patients, and physical examination of patients – remain very essential to making and reaching a complete and accurate diagnosis. Expensive laboratory and imaging diagnostics while very relevant, should not replace these age-old skills that have served to enhance and maintain the doctor-patient relationship and human connection, a connection that is often necessary for healing. Cases in Clinical Infectious Disease Practice uses case studies to illustrate how the infectious disease clinician processes and integrates data to arrive at a diagnosis. This type of hands-on approach, invaluable in training programs, is utilized to take the reader through initial patient encounter, through the history and physical examination, to simple laboratory findings and stains, to a final diagnosis, in a way that is easily accessible to clinicians, students, and laboratory personnel working with clinical specimens. Appeals to practitioners of all levels, with focus on patients with common problems or complications of common infections without heavy technical language Emphasizes basic clinical skills including history taking, observation, epidemiology, and physical exam, as well as simple laboratory tests, explaining how they lead to a reasonable diagnosis Presents cases seen first-hand within the community setting, reflective of cases or situations a resident or student is likely to encounter in the real world after training Cases in Clinical Infectious Disease Practice is an essential resource for clinicians, graduate and medical school students, and others conducting medical and clinical microbiology or infectious disease research on real patients.

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

Etiology-Based Dental and Craniofacial Diagnostics explores the role of embryology and fetal pathology in the assessment, diagnosis, and subsequent treatment planning of a wide range of disorders in the dentition and craniofacial region. Initial chapters cover various aspects of normal dental and craniofacial development, providing the necessary biological background for understanding abnormal patient cases. Chapters then focus on the etiology behind a wide range of cases observed in everyday practice—including deviations in tooth morphology and number, tooth eruption, root and crown resorption, and craniofacial malformations, disruptions and dysplasia. Unique new work from a leading authority in orthodontics, craniofacial embryology and fetal pathology Demonstrates how human prenatal development offers unique insights into postnatal diagnosis and treatment Clinical significance and implications are highlighted in summaries at the end of each chapter Ideal for postgraduate students in orthodontics, paediatric dentistry and oral medicine

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection • Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing