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Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

This fully updated edition of Infectious Disease Surveillance is for frontline public health practitioners, epidemiologists, and clinical microbiologists who are engaged in communicable disease control. It is also a foundational text for trainees in public health, applied epidemiology, postgraduate medicine and nursing programs. The second edition portrays both the conceptual framework and practical aspects of infectious disease surveillance. It is a comprehensive resource designed to improve the tracking of infectious diseases and to serve as a starting point in the development of new surveillance systems. Infectious Disease Surveillance includes over 45 chapters from over 100 contributors, and topics organized into six sections based on major themes. Section One highlights the critical role surveillance plays in public health and it provides an overview of the current International Health Regulations (2005) in addition to successes and challenges in infectious disease eradication. Section Two describes surveillance systems based on logical program areas such as foodborne illnesses, vector-borne diseases, sexually transmitted diseases, viral hepatitis healthcare and transplantation associated infections. Attention is devoted to programs for monitoring unexplained deaths, agents of bioterrorism, mass gatherings, and disease associated with international travel. Sections Three and Four explore the uses of the Internet and wireless technologies to advance infectious disease surveillance in various settings with emphasis on best practices based on deployed systems. They also address molecular laboratory methods, and statistical and geospatial analysis, and evaluation of systems for early epidemic detection. Sections Five and Six discuss legal and ethical considerations, communication strategies and applied epidemiology-training programs. The rest of the chapters offer public-private partnerships, as well lessons from the 2009-2010 H1N1 influenza pandemic and future directions for infectious disease surveillance.

Practical Transfusion Medicine, Fourth Edition Edited by Michael F. Murphy, Professor of Blood Transfusion Medicine, University of Oxford; Consultant Haematologist, NHS Blood and Transplant and Oxford University Hospitals, Oxford, UK Derwood H. Pamphilon, formerly Consultant Haematologist, NHS Blood and Transplant; Honorary Clinical Reader, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK Nancy M. Heddle, Director, MTRP, Professor, Department of Medicine, McMaster University, Hamilton, Ontario, Canada The pace of change in transfusion medicine is relentless, with new scientific and technological developments. In addition, efforts are continuing to improve clinical transfusion practice and avoid the use of blood wherever possible. This fourth edition continues to be a concise and comprehensive guide to transfusion medicine. It has been thoroughly revised and updated throughout. The scope of the book has been broadened by including more international authors and a new co-editor, Professor Nancy Heddle, an expert in evidence-based transfusion medicine. Practical Transfusion Medicine is divided into seven main parts, each of which guide the reader systematically through the key areas of the speciality: – Principles of transfusion medicine – Complications of transfusion – Practice in blood centres and hospitals – Clinical transfusion practice – Alternatives to transfusion – Cellular and tissue therapy and organ transplantation – Development of the evidence base for transfusion This book is ideal for trainee/resident haematologists revising for examinations and as a reference source for clinical and scientific staff working in the field of transfusion medicine. Titles of related interest Klein: Mollison’s Blood Transfusion in Clinical Medicine, 11e ISBN 9780632064540 (forthcoming 2013) De Vries: Hemovigilance: An Effective Tool for Improving Transfusion Safety ISBN 9780470655276 (August 2012) McCullough: Transfusion Medicine, 3e ISBN 978144433705 (December 2011)

Illustrating the differences between urgent interventions and interventions performed to manage chronic conditions the authors present the chapters in a consistent template for ease of use covering; background, indications, evidence review, device description, procedural techniques, follow-up care, and complications. Shows the differences between interventions performed to manage chronic conditions and interventions that are truly urgent Chapters follow a consistent structure from background through indications, evidence review, device description, procedural techniques to follow-up care and complications More than 40 high definition videos, hosted on companion website www.wiley.com/go/kipshidze/interventionaltherapies, complete with tips and tricks, provide a visual learning tool

Global movement of people leads to the global movement of disease International travel enables skin diseases to move around the world with increasing ease. Skin diseases transmitted through casual contact with people, animal vectors and a foreign environment are particularly prone to transport. Dermatologists need to recognize the signs and symptoms of disease not native to their environment to enable proper diagnosis and care. Imported Skin Diseases provides a clinical guide to the foreign diseases increasingly seen in ‘Western’ clinics. With a focus on accurate diagnosis and effective therapy, the book covers: Differences between pigmented and non-pigmented skin Viral, bacterial and fungal Infections Parasitic infestations Sexually transmitted diseases Aquatic diseases Written by an international team of experts, with practical tips throughout, Imported Skin Diseases prepares you for the unusual skin diseases you are increasingly likely to see in your clinic.

First published in 1958, Diseases of Swine, Tenth Edition is a fully revised and updated version of this classic reference. Now published in association with the American Association of Swine Veterinarians, the Tenth Edition adds new knowledge throughout in a reorganized format to provide more intuitive access to information. With chapters written by more than 150 of the foremost experts in the field, Diseases of Swine remains the premier source of comprehensive information on swine production, health, and management for swine health specialists of all disciplines and at any level of expertise, including veterinarians, researchers, and students. Featuring a new content organization designed for improved navigability, the Tenth Edition adds chapters on the cardiovascular system, diagnostic tests and test performance, food safety and zoonotic diseases, show and pet pigs, and the most current information on both long-recognized and emerging pathogens. Diseases of Swine, Tenth Edition is an indispensable resource for anyone interested in swine health.

Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations. This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globally. From an international team of expert contributors Pediatric Drug Development: Concepts and Applications is the practical guide to all aspects of the research and development of safe and effective medicines for children.

Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists,Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in-depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

The new and updated edition of the renowned reference for pediatric oncologists This groundbreaking text on the management of childhood cancers covers most tumor types occurring in children and young adults and provides reviews of randomized trials with commentaries on the optimum treatments for childhood cancer. Updated with evidence from the latest published reviews—and even more clinically focused than previous editions— Evidence-Based Pediatric Oncology, Third Edition places an emphasis on application of the trial findings. With increased coverage of the area of supportive care for pediatric cancer patients, each chapter opens with an expert commentary on the key clinical issues followed by a summary of trial findings. Evidence-Based Pediatric Oncology, Third Edition: • Presents evidence for the best treatment of children and adolescents with cancer • Includes commentaries from the world’s leading experts for every topic discussed • Is internationally relevant thanks to contributions from the UK, US, Canada and Australia • Places greater emphasis on supportive care and features a new extended section on antibiotic and antifungal treatments Based on information gathered from randomized trials performed after the release of the Second Edition, readers will find Evidence-Based Pediatric Oncology to be an important resource for all those treating young people with cancer.

Anesthesia and the Fetus integrates into one volume the multidisciplinary components of: fetal development fetal pharmacology assessments of fetal and neonatal outcome anesthesia and analgesia during pregnancy anesthesia and analgesia during labor ethics and law Written by an internationally renowned group of clinicians and scientists, Anesthesia and the Fetus provides a contemporary guide and reference to the role of anesthesia, and the anesthesiologist, in protecting the mother and her unborn child during pregnancy.

Wiley-Blackwell's Clinical Cases series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Orthodontics applies both theory and practice to real-life orthodontic cases in a clinically relevant format. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from Class I malocclusions to orthognathic surgery. Highly illustrated in full color, Clinical Cases in Orthodontics' format fosters independent learning and prepares the reader for case-based examinations.