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In this pathbreaking volume, a multidisciplinary team of international experts puts catheter–based treatment techniques in context by exploring the pathobiology of specific diseases alongside a discussion of imaging tools and functional tests, and a comparison to alternative treatment approaches provided by cardiovascular surgery. This comprehensive overview of interventional cardiology: Explains treatments in depth, including imaging techniques and functional tests Serves as both a theoretical and practical guide to available treatment approaches that can be tailored for individual patients Provides the latest scientific data and new surgical alternatives Presents a practically oriented view of the most important interventional strategies Is written by a strong team of well-published and highly-regarded authors, the people whose breakthroughs in the clinic and the lab have made interventional cardiology the dynamic field it is today Practitioners, fellows, and trainees who want a state-of-the-art guide to interventional cardiology can depend on this carefully crafted guide for authoritative information.

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Practical Endocrinology and Diabetes in Children is the ideal bench-side companion for the practising paediatrician and endocrinologist, bridging the gap between large reference books and short reviews of aspects of endocrinology. This third edition contains a variety of new features such as key web links, guidelines, case studies illustrating diagnostic difficulties which will help all those studying for postgraduate examinations such as the MRCPCH. The book provides a highly clinical, concise and up-to-date account of paediatric endocrinology and diabetes in a clear and user friendly format. There are sections on how to deal with emergencies, as well as information on potential pitfalls, controversial areas and future developments. Practical Endocrinology and Diabetes in Children is an essential guide for trainee paediatricians, paediatric endocrinologists and diabetologists as well as diabetes and endocrinology nurse specialists.

Evidence Informed Nursing with Older People is an essential text for nursing students and registered nurses working with older people who are seeking to make connections between theory, evidence and value based gerontological practice. The rapidly rising aging global population requires that more attention is given to the needs and requirements of older people. This textbook is a key resource for nursing students and registered nurses working with older people who wish to improve their practice. Evidence Informed Nursing with Older People takes a unique case-study approach, with individual chapters presenting nursing practice-based case studies on some of the most common areas of care faced by nurses working around the world with older people. Each case study illustrates the connections between practice, theory, evidence and values. User-friendly and accessible, this textbook includes key points, reflection activities, test points, and perspectives from older people throughout. Key features An up-to-date treatment of the nursing contribution to key geriatric syndromes International expert contributions from the UK, Sweden, Switzerland, Australia and China An evidence-based, case-study approach to the care of older people

Reproductive hemostasis: A global approach to a global challenge A hemostatic change in women through their reproductive lifetime is emerging as an issue of global importance. No wonder, as obstetric hemorrhage remains a major cause of maternal mortality in both developed and developing countries. Thrombophilias and pulmonary embolisms are a threat to maternal and fetal well-being. Hemostasis and Thrombosis in Obstetrics & Gynecology provides a framework for assessing and managing hemostatic disorders in women. Written by an international team, it provides globally applicable guidelines for obstetric hematology. The practical approach to clinical management includes: Hematologic changes in pregnancy Red cell disorders Platelet disorders Inherited and acquired thrombophilia Inherited bleeding disorders Postpartum hemorrhage Blood and bleeding disorders in women can be managed by obstetrician-gynecologists or hematologists, separately or together. Hemostasis and Thrombosis in Obstetrics & Gynecology provides specialists from both disciplines with the information necessary to manage their patients effectively.

Meeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron The new edition is a key reference source for all those involved in the practice of blood management and conservation.

Zoo Animal and Wildlife Immobilization and Anesthesia, Second Edition is a fully updated and revised version of the first comprehensive reference on anesthetic techniques in captive and free-ranging wildlife. Now including expanded coverage of avian and aquatic species, this exhaustive resource presents information on the full range of zoo and wildlife species. Covering topics ranging from monitoring and field anesthesia to CPR and euthanasia, the heart of the book is devoted to 53 species-specific chapters providing a wealth of information on little-known and common zoo and wildlife animals alike. In addition to new species chapters, the new edition brings a new focus on pain management, including chronic pain, and more information on species-specific physiology. Chapters on airway management, monitoring, emergency therapeutics, and field procedures are all significantly expanded as well. This update to Zoo Animal and Wildlife Immobilization and Anesthesia is an invaluable addition to the library of all zoo and wildlife veterinarians.

Health protection professionals need rapid access to authoritative and easy-to-use information to ensure their actions are based on international best practice. This is precisely what the Communicable Disease Control and Health Protection Handbook does. This concise and practical handbook is an essential guide for all those who have responsibility for the identification and control of infectious disease. In the past five years, there have been many major changes in health protection practice, and significant scientific progress in the field, all of which are reflected in this new edition of the popular Communicable Disease Control and Health Protection Handbook. All chapters have been updated in line with recent changes in epidemiology, new guidelines for control and administrative changes. Basic principles of communicable disease control and health protection, major syndromes, control of individual infections, main services and activities, organizational arrangements for all EU countries and sources of further information are covered. A new chapter on pandemic planning has been included, and the influenza chapter has been expanded to cover seasonal, avian and pandemic flu. Communicable Disease Control and Health Protection Handbook is an indispensible companion for all those who are engaged in health protection, including public health physicians, epidemiologists, infection control nurses, microbiologists and trainees in the field.

Extraordinary advances in the understanding of the links between nutrition, metabolism, and cardiovascular disease have prompted a systematic reappraisal of knowledge in the field. As a result, it is now imperative that clinicians who care for patients with CVD or its key risk factors have a solid understanding of the often complex interrelationships between cardiovascular health and chronic diseases such as diabetes and obesity. Written by a team of international thought leaders in cardiology, endocrinology, diabetology and nutritional science, this important new book: Examines and updates the role of obesity, hyperlipidemia, diabetes, hypertension, thrombosis, and aging in atherogenesis Describes in detail the scientific and clinical evidence of the etiopathogenesis of ischemic heart disease as well as of peripheral and cerebrovascular disease Focuses on the 6 topics that will be of greatest interest to readers: 1) general nutrition, 2) metabolic syndrome and diabetes, 3) hyperlipidemia and atherosclerosis, 4) hypertension and cerebrovascular disease, 5) hemostasis and thrombosis, 6) aging Throughout the book, in clear and accessible text, contributors illuminate the close relationship between dietary habits, the metabolic processes of nutrients, and their impact on the cardiovascular system, always with an eye on how the physician can use this information to implement better cardiovascular prevention and improve patient care. Nutritional and Metabolic Bases of Cardiovascular Disease is ideal for those who need to update their knowledge of the links between nutrition, metabolism and CVD, from trainees, clinicians and clinical investigators in cardiovascular medicine to endocrinologists, diabetologists, and nutritionists.

Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

This handbook and ready reference presents a combination of statistical, information-theoretic, and data analysis methods to meet the challenge of designing empirical models involving molecular descriptors within bioinformatics. The topics range from investigating information processing in chemical and biological networks to studying statistical and information-theoretic techniques for analyzing chemical structures to employing data analysis and machine learning techniques for QSAR/QSPR. The high-profile international author and editor team ensures excellent coverage of the topic, making this a must-have for everyone working in chemoinformatics and structure-oriented drug design.

Improve your skills in visual diagnosis Speed and accuracy of diagnosis is the key to saving lives in emergency and critical care medicine. Careful visual inspection of the patient, the data (radiography, electrocardiogram), and related clues can often help providers choose the right diagnosis and ultimately the best treatment – but this knowledge comes with experience. This book provides 110 randomly presented visual diagnosis cases for self-testing, imitating real-life situations found in the emergency department setting. Written by distinguished emergency and critical care physicians, and thoroughly revised and updated throughout, this second edition includes 25% new cases and is an ideal aid for trainees preparing for Board examinations as well as an invaluable ‘refresher’ for qualified emergency and critical care providers. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.