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Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach. From the contents: * Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies * Modulators of protein-protein interactions: The importance of Three-Dimensionality * Interactive technologies for leveraging the known chemistry of anchor residues * SH3 Domains as Drug Targets * P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments * Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases * The PIF-binding pocket of AGC kinases * Peptidic inhibitors of protein-protein interactions for cell adhesion receptors * The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases and more

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Flow Cytometry of Hematological Malignancies contains an array of graphical outputs produced by the technique in the study of the most (and the least) common diseases. The images included allow you to compare your own results with a third party reference pattern. There is a detailed description of the main leukocyte antigens, together with a description of their distribution amongst normal and abnormal blood cells. The book also provides a comprehensive description of the phenotype of every neoplastic blood disease recorded in the WHO classification system, including all the instructions needed to recognise and classify even the least common entity. Designed to be practical, the book is perfect for quick consultation and is divided into two main sections. Section I deals with the direct object of immunophenotyping, and Section II deals with the ultimate target of the analysis. More than 50 antigens are covered and every antigen is dealt with in three main parts: general features, cytometric features and practical hints. This authoritative and state-of-the-art reference will be invaluable for clinicians directly involved in the diagnosis and analysis of hematological diseases, including hematologists, hematopathologists, oncologists, pathologists and technicians working in diagnostic laboratories.

Endoscopy is the primary diagnostic method for GI complaints and is replete with an ever expanding array of therapeutic capabilities. Successful Training in Gastrointestinal Endoscopy will provide all gastroenterologists with the exact set of skills required to perform endoscopy at the highest level. GI trainees will find it a crucial primer for learning endoscopy; teachers will find it a guide to understand how best to develop the expertise of their students; and experienced practicing gastroenterologists will find it a useful refresher tool to brush up on their existing endoscopic skills and to familiarise themselves with new procedures, including issues of safety and competence while performing them. With contributions from internationally recognized leaders in endoscopy education and an endorsement by the World Organisation of Digestive Endoscopy, each chapter will examine the specific skill sets and procedure related tasks which must be mastered when learning a particular technique, including: Specific descriptions of accessories required Standard training methods for the procedure Optimal utilization of novel learning modalities such as simulators Quality measures and objective parameters for competency Available tools for assessing competency once training has been completed In addition to the 400 high-quality, outstanding colour photos, the book will come with a DVD containing over 130 annotated teaching videos of both actual procedures and ex-vivo animal model simulations. These videos will illustrate, in a step by step fashion the proper techniques to be followed, highlighting clinical pearls from the experts and the most common mistakes to avoid. Successful Training in Gastrointestinal Endoscopy will be a key purchase for all gastroenterologists, whether in training or experienced, to allow them to develop and perfect their endoscopic skills. It will be a particularly useful guide for those interested in mastering the latest new techniques and procedures and an essential reference for teachers of endoscopy and students alike. Note: DVD and other supplementary materials are not included as part of eBook file. These materials are available for download upon purchase.

Orthodontic Treatment of Impacted Teeth provides its readers with a gold-standard resource to tackle common, complex and multi-factorial clinical scenarios. Rooted firmly in the scientific reality, it also provides a valuable repository of the evidence-base for this subject area. The third edition of this classic text has been fully revised and updated to reflect the latest advances in research and clinical practice. It discusses recent developments in the periodontal outcome of surgical exposure of impacted teeth, and also incorporates more protocols for routine cases. This enables clinicians to develop their skills in the simpler cases, as well as to improve their understanding of complex and rare presentations. An especially useful chapter looks at failure and impending failure, providing a valuable insight into the real life management of impacted teeth. The author describes how to recognize failure and proposes ways to avoid it, frequently illustrating them with cases from his own clinic. KEY FEATURES • Fully revised and updated classic • Coverage expanded to include protocols for routine, as well as complex cases • Includes new chapter on extreme tooth displacement and complicating factors • Provides unparalleled coverage of the evidence base • Highly illustrated in full colour

This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with 'Recommendations' based on strong evidence and 'Good Practice Points' where only weaker evidence is available. The Guidelines in this volume include, amongst others: Neurostimulation therapy for neuropathic pain Molecular diagnosis for a range of neurological conditions Intravenous immunoglobulin in the treatment of neurological diseases Sleep disorders in neurodegenerative disorders and stroke Management of low-grade gliomas Treatment of miscellaneous idiopathic headache disorders The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles. Titles of related interest Cerebrovascular Ultrasound in Stroke Prevention, 2e Alexandrov (ed); ISBN 9781405195768 Parkinsons's Disease: Non-Motor and Non-Dopaminergic Features Olanow, Stocchi and Lang (eds); ISBN 9781405191852 Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment Albanese and Jankovic (eds); ISBN 9781444333527

Minimally invasive surgical techniques are moving into the mainstream of urological practice. Even less invasive techniques, some of which can involve no use of the knife whatsoever, are rapidly being developed and implemented for treating urological cancer. Interventional Techniques in Uro-oncology is the first text to cover these techniques in total and provides a comprehensive review of the state-of-the-art minimally invasive interventions. This well-illustrated reference provides the basic science behind each technique before explaining when and how best to perform them. It examines their use in different clinical settings, the advantages and disadvantages of each technique in the management of specific tumor types, and their suitability for different patients. Future techniques are discussed including the potential of nanotechnology in the delivery of urologic healthcare. Each chapter is easy to navigate with key points and references. Interventional Techniques in Uro-oncology is an essential reference for training and practicing oncologists, urologists and radiologists as well as the general physician with a keen interest in cancer care. Its approachable style will also inform non-experts on what is available and whether a particular intervention is suitable for their patient in the clinic.

How can the needs and perspective of patients be incorporated in the design and redesign of health services? Health organizations are focusing more and more on patients – and requiring their employees to practise patient focused care. The Modernisation Initiative described in this book explores in three health service areas (kidney, stroke and sexual health services) how patients' and carers' involvement may inform and shape quality improvement work This book guides you through the issues and challenges that teams seeking to involve users in changing health services are likely to face. It offers a wealth of practical knowledge about involving users. Those undertaking similar programmes, whether in primary care or hospital based, will find ideas and examples in this book to inspire and guide them.

Experience and evidence fused for best-practice management of high-risk pregnancies High-risk pregnancies present life-threatening challenges to two of your patients: the mother and her fetus. The direct, exemplary guidance in Protocols for High-Risk Pregnancy enables you to: better understand your patients' conditions devise optimum management strategies maximize the outcome and minimize the complications for both the mother and her fetus To enhance clinical relevance, each protocol is written as if the patient were present. Evidence to support an intervention is given where it exists. The authors' experience provides additional wise counsel. Key references provide the springboard for a deeper understanding of a topic. All protocols have been updated. New protocols follow the successful formula of previous editions. Watch an interview with Dr John T. Queenan and Dr Catherine Y. Spong here: http://www.youtube.com/watch?v=pdgqNUOtnk4