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Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic sequence under investigation. The AGT Cytogenetics Laboratory Manual, Fourth Edition offers a comprehensive description of the diagnostic tests offered by the clinical laboratory and explains the science behind them. One of the most valuable assets is its rich compilation of laboratory-tested protocols currently being used in leading laboratories, along with practical advice for nearly every area of interest to cytogeneticists. In addition to covering essential topics that have been the backbone of cytogenetics for over 60 years, such as the basic components of a cell, use of a microscope, human tissue processing for cytogenetic analysis (prenatal, constitutional, and neoplastic), laboratory safety, and the mechanisms behind chromosome rearrangement and aneuploidy, this edition introduces new and expanded chapters by experts in the field. Some of these new topics include a unique collection of chromosome heteromorphisms; clinical examples of genomic imprinting; an example-driven overview of chromosomal microarray; mathematics specifically geared for the cytogeneticist; usage of ISCN’s cytogenetic language to describe chromosome changes; tips for laboratory management; examples of laboratory information systems; a collection of internet and library resources; and a special chapter on animal chromosomes for the research and zoo cytogeneticist. The range of topics is thus broad yet comprehensive, offering the student a resource that teaches the procedures performed in the cytogenetics laboratory environment, and the laboratory professional with a peer-reviewed reference that explores the basis of each of these procedures. This makes it a useful resource for researchers, clinicians, and lab professionals, as well as students in a university or medical school setting.

Why do earthquakes happen? What properties control the dynamic rupture and what are the processes at play? Chapters in the present volume capture the current state of the art by displaying an overview of the existing knowledge on the physics of dynamic faulting and promote multidisciplinary contributions on the observational and experimental fault fabric and mechanics, the evolution of fault zone physical and chemical properties, dynamic rupture processes and physically, and observationally, consistent numerical modeling of fault zone during seismic rupture. This volume examines questions such as: What are the dynamics processes recorded in fault gouge? What can we learn on rupture dynamic from laboratory experiments? How on-fault and off-fault properties affect seismic ruptures? How do they evolve trough time? Insights from physically, and observationally, consistent numerical modeling Fault Zone Dynamic Processes: Evolution of Fault Properties During Seismic Rupture is a valuable contribution for Earth’s scientists, researchers and students interested in the earthquakes processes and properties of on-fault and off-fault zones. Its multidisciplinary content is relevant to a broad audience: structural geologist, experimentalists, rocks mechanicians, seismologist, geophysicists and modelers.

Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems. • Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use • Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology • Retains a succinct chapter format that has become the hallmark for the previous editions • Distils a vast amount of information into one resource for both academics and professionals

A valuable handbook containing reviews, practical methods and standard operating procedures. A valuable and practical working handbook containing introductory and specialist content that tackles a major and growing field of environmental, microbiological and ecotoxicological monitoring and analysis Includes introductory reviews, practical analytical chapters and a comprehensive listing of almost thirty Standard Operating Procedures (SOPs) For use in the laboratory, in academic and government institutions and industrial settings

Several scholars across the globe identified the present lack of high quality damage data as the main constraint to efficient risk mitigation. The need for a systematic collection of damage data in the aftermath of flood events come into light, thus the aim being the creation of complete and reliable databases. Flood damage data collected in the aftermath of a disastrous event can support a variety of actions, which include: (i) the identification of priorities for intervention during emergencies, (ii) the creation of complete event scenarios on the basis of which understanding the fragilities of the flooded areas and tailoring risk mitigation strategies, (iii) the definition of victims compensation schemes, and (iv) the validation/definition of damage models to feed cost-benefit analysis of structural and non-structural mitigation actions (including insurance schemes). Volume highlights include: A good compilation of real world case studies elaborating on the survey experiences and best practices associated with flood damage data collection, storage and analysis, that can help strategize flood risk mitigation in an efficient manner Valuable contributions covering different flooding phenomena such as riverine and mountain floods, different spatial level of analysis from local to global scales, and different stakeholders perspectives, e.g. public decision makers, researchers, private companies Contributions from leading experts in the field, researchers and practitioners, including civil protection actors working at different spatial and administrative level, insurers and professionals working in the field of natural hazards mitigation Flood Damage Survey and Assessment: New Insights from Research and Practice will be a valuable resource to all earth scientists, hydrologists, meteorologists, geologists, geographers, civil engineers, insurers and policy decision makers.

Brain–computer interfaces (BCI) are devices which measure brain activity and translate it into messages or commands, thereby opening up many investigation and application possibilities. This book provides keys for understanding and designing these multi-disciplinary interfaces, which require many fields of expertise such as neuroscience, statistics, informatics and psychology. This first volume, Methods and Perspectives, presents all the basic knowledge underlying the working principles of BCI. It opens with the anatomical and physiological organization of the brain, followed by the brain activity involved in BCI, and following with information extraction, which involves signal processing and machine learning methods. BCI usage is then described, from the angle of human learning and human-machine interfaces. The basic notions developed in this reference book are intended to be accessible to all readers interested in BCI, whatever their background. More advanced material is also offered, for readers who want to expand their knowledge in disciplinary fields underlying BCI. This first volume will be followed by a second volume, entitled Technology and Applications

Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the “openness” of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.

Filling the need for a solid textbook, this short primer in cluster science is ideal for a one-semester lecture for advanced undergraduate students. It is based on a series of lectures given by the well-established and recognized authors for the past ten years. The book covers both the basics of the domain as well as up-to-date developments. It can be divided roughly into two parts. The first three chapters introduce basic concepts of cluster science. Chapter 1 provides a general introduction, complemented by chapter 2 on experimental and chapter 3 on theoretical aspects. The second half of the book is devoted to a systematic presentation of free cluster properties, and to a thorough discussion of the impact of clusters in other domains of science. These explicitly worked-out links between cluster physics and other research areas are unique both in terms of fundamental aspects and of applications, and cannot be found elsewhere in the literature. Also suitable for researchers outside of the field looking for an introduction to cluster science.

Wine chemistry inspires and challenges with its complexity, and while this is intriguing, it can also be a barrier to further understanding. The topic is demystified in Understanding Wine Chemistry, which explains the important chemistry of wine at the level of university education, and provides an accessible reference text for scientists and scientifically trained winemakers alike. Understanding Wine Chemistry: Summarizes the compounds found in wine, their basic chemical properties and their contribution to wine stability and sensory properties Focuses on chemical and biochemical reaction mechanisms that are critical to wine production processes such as fermentation, aging, physiochemical separations and additions Includes case studies showing how chemistry can be harnessed to enhance wine color, aroma, flavor, balance, stability and quality. This descriptive text provides an overview of wine components and explains the key chemical reactions they undergo, such as those controlling the transformation of grape components, those that arise during fermentation, and the evolution of wine flavor and color. The book aims to guide the reader, who perhaps only has a basic knowledge of chemistry, to rationally explain or predict the outcomes of chemical reactions that contribute to the diversity observed among wines. This will help students, winemakers and other interested individuals to anticipate the effects of wine treatments and processes, or interpret experimental results based on an understanding of the major chemical reactions that can occur in wine.

The use of computation and simulation has become an essential part of the scientific process. Being able to transform a theory into an algorithm requires significant theoretical insight, detailed physical and mathematical understanding, and a working level of competency in programming. This upper-division text provides an unusually broad survey of the topics of modern computational physics from a multidisciplinary, computational science point of view. Its philosophy is rooted in learning by doing (assisted by many model programs), with new scientific materials as well as with the Python programming language. Python has become very popular, particularly for physics education and large scientific projects. It is probably the easiest programming language to learn for beginners, yet is also used for mainstream scientific computing, and has packages for excellent graphics and even symbolic manipulations. The text is designed for an upper-level undergraduate or beginning graduate course and provides the reader with the essential knowledge to understand computational tools and mathematical methods well enough to be successful. As part of the teaching of using computers to solve scientific problems, the reader is encouraged to work through a sample problem stated at the beginning of each chapter or unit, which involves studying the text, writing, debugging and running programs, visualizing the results, and the expressing in words what has been done and what can be concluded. Then there are exercises and problems at the end of each chapter for the reader to work on their own (with model programs given for that purpose).

Dawn­Dusk Asymmetries in Planetary Plasma Environments Dawn-dusk asymmetries are ubiquitous features of the plasma environment of many of the planets in our solar system. They occur when a particular process or feature is more pronounced at one side of a planet than the other. For example, recent observations indicate that Earth's magnetopause is thicker at dawn than at dusk. Likewise, auroral breakups at Earth are more likely to occur in the pre-midnight than post-midnight sectors. Increasing availability of remotely sensed and in situ measurements of planetary ionospheres, magnetospheres and their interfaces to the solar wind have revealed significant and persistent dawn-dusk asymmetries. As yet there is no consensus regarding the source of many of these asymmetries, nor the physical mechanisms by which they are produced and maintained. Volume highlights include: A comprehensive and updated overview of current knowledge about dawn-dusk asymmetries in the plasma environments of planets in our solar system and the mechanisms behind them Valuable contributions from internationally recognized experts, covering both observations, simulations and theories discussing all important aspects of dawn-dusk asymmetries Space weather effects are caused by processes in space, mainly the magnetotail, and can be highly localized on ground. Knowing where the source, i.e., where dawn-dusk location is will allow for a better prediction of where the effects on ground will be most pronounced Covering both observational and theoretical aspects of dawn dusk asymmetries, Dawn­-Dusk Asymmetries in Planetary Plasma Environments will be a valuable resource for academic researchers in space physics, planetary science, astrophysics, physics, geophysics and earth science.

Winner of the IENE Project Award 2016. This authoritative volume brings together some of the world’s leading researchers, academics, practitioners and transportation agency personnel to present the current status of the ecological sustainability of the linear infrastructure – primarily road, rail and utility easements – that dissect and fragment landscapes globally. It outlines the potential impacts, demonstrates how this infrastructure is being improved, and how broad ecological principles are applied to mitigate the impact of road networks on wildlife. Research and monitoring is an important aspect of road ecology, encompassing all phases of a transportation project. This book covers research and monitoring to span the entire project continuum – starting with planning and design, through construction and into maintenance and management. It focuses on impacts and solutions for species groups and specific regions, with particular emphasis on the unique challenges facing Asia, South America and Africa. Other key features: Contributions from authors originating from over 25 countries, including from all continents Each chapter summarizes important lessons, and includes lists of further reading and thoroughly up to date references Highlights principles that address key points relevant to all phases in all road projects Explains best-practices based on a number of successful international case studies Chapters are «stand-alone», but they also build upon and complement each other; extensive cross-referencing directs the reader to relevant material elsewhere in the book Handbook of Road Ecology offers a comprehensive summary of approximately 30 years of global efforts to quantify the impacts of roads and traffic and implement effective mitigation. As such, it is essential reading for those involved in the planning, design, assessment and construction of new roads; the management and maintenance of existing roads; and the modifying or retrofitting of existing roads and problem locations. This handbook is an accessible resource for both developed and developing countries, including government transportation agencies, Government environmental/conservation agencies, NGOs, and road funding and donor organisations.