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This practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.

The Wave Concept Iterative Procedure (WCIP) method has found an increasing number of users within electromagnetic theory and applications to planar circuits, antennas and diffraction problems. This book introduces in detail this new formulation of integral methods, based on the use of a wave concept with two bounded operators, and applications in a variety of domains in electromagnetics. This approach presents a number of benefits over other integral methods, including overcoming the problem of singularity, and reduced computing time. Through the presentation of mathematical equations to characterize studied structures and explanation of the curves obtained, via validated examples, the authors provide a thorough background to electromagnetism as well as a professional reference to students and researchers.

Forest trees and shrubs play vital ecological roles, reducing the carbon load from the atmosphere by using carbon dioxide in photosynthesis and by the storage of carbon in biomass and wood as a source of energy. Autoecology deals with all aspects of woody plants; the dynamism of populations, physiological traits of trees, light requirements, life history patterns, and physiological and morphological characters. Ecophysiology is defined by various plant growth parameters such as leaf traits, xylem water potential, plant height, basal diameter, and crown architecture which are, in turn, influenced by physiological traits and environmental conditions in the forest ecosystem. In short, this book details research advances in various aspects of woody plants to help forest scientists and foresters manage and protect forest trees and plan their future research. Autoecology and Ecophysiology of Woody Shrubs and Trees is intended to be a guide for students of woody plant autoecology and ecophysiology, as well as for researchers in this field. It is also an invaluable resource for foresters to assist in effective management of forest resources.

Medical technology is a fast growing field. This new title gives a comprehensive review of modern optical technologies alongside their clinical deployment. It bridges the technology and clinical domains and will be suitable in both technical and clinical environments. It introduces and develops basic physical methods (in optics, photonics, and metrology) and their applications in the design of optical systems for use in medical technology with a special focus on ophthalmology. Medical applications described in detail demonstrate the advantage of utilizing optical-photonic methods. Exercises and solutions for each chapter help understand and apply basic principles and methods. An associated website run by the authors will include slides to facilitate the teaching/training of this material, and typical images collected by the described methods, eg videos of endoscopy or navigation, OCT, etc.

Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a «who's who» in multicomponent reaction chemistry, this is definitely a must-have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.

Uncertainties are pervasive in natural hazards, and it is crucial to develop robust and meaningful approaches to characterize and communicate uncertainties to inform modeling efforts. In this monograph we provide a broad, cross-disciplinary overview of issues relating to uncertainties faced in natural hazard and risk assessment. We introduce some basic tenets of uncertainty analysis, discuss issues related to communication and decision support, and offer numerous examples of analyses and modeling approaches that vary by context and scope. Contributors include scientists from across the full breath of the natural hazard scientific community, from those in real-time analysis of natural hazards to those in the research community from academia and government. Key themes and highlights include: Substantial breadth and depth of analysis in terms of the types of natural hazards addressed, the disciplinary perspectives represented, and the number of studies included Targeted, application-centered analyses with a focus on development and use of modeling techniques to address various sources of uncertainty Emphasis on the impacts of climate change on natural hazard processes and outcomes Recommendations for cross-disciplinary and science transfer across natural hazard sciences This volume will be an excellent resource for those interested in the current work on uncertainty classification/quantification and will document common and emergent research themes to allow all to learn from each other and build a more connected but still diverse and ever growing community of scientists.

With the expectation of greatly enhanced user experience, 3D video is widely perceived as the next major advancement in video technology. In order to fulfil the expectation of enhanced user experience, 3D video calls for new technologies addressing efficient content creation, representation/coding, transmission and display. Emerging Technologies for 3D Video will deal with all aspects involved in 3D video systems and services, including content acquisition and creation, data representation and coding, transmission, view synthesis, rendering, display technologies, human perception of depth and quality assessment. Key features: Offers an overview of key existing technologies for 3D video Provides a discussion of advanced research topics and future technologies Reviews relevant standardization efforts Addresses applications and implementation issues Includes contributions from leading researchers The book is a comprehensive guide to 3D video systems and services suitable for all those involved in this field, including engineers, practitioners, researchers as well as professors, graduate and undergraduate students, and managers making technological decisions about 3D video.

A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Kompakt und »verdammt clever« auf den Punkt gebracht – vermittelt Molekularbiologie das unverzichtbare Grundwissen zu Struktur, Biosynthese und Funktion von DNA und RNA und erklärt, wie diese untereinander und mit Proteinen interagieren. Endlich ein maßgeschneidertes Kurzlehrbuch für Studenten, die auf der Suche nach einer knappen Einführung in dieses grundlegende Fachgebiet sind: • Ideal für Einsteiger! Beschränkt sich auf die wirklich wichtigen Themen der Molekularbiologie und fasst die wesentlichen Fakten und Begriffe für jedes Thema zusammen. • Einprägsam! Klare Abbildungen erleichtern das Lernen und Verstehen, Querverweise auf verwandte Kapitel zeigen Zusammenhänge auf und fördern so das Verständnis. • Ausgezeichnete Prüfungsvorbereitung! Ermöglicht strukturiertes Lernen und schnelles Wiederholen durch einzigartigen Kapitelaufbau – mit über 70 Fragen und Antworten.

This introductory level text explores various theoretical approaches to human-environment geography, demonstrating how local dynamics and global processes influence how we interact with our environments. Introduces students to fundamental concepts in environmental geography and science Explores the core theoretical traditions within the field, along with major thematic issues such as population, food and agriculture, and water resources Offers an engaging and unique view of the spatial relationships between humans and their environment across geographical locations around the world Includes a variety of real-world policy questions and emphasizes geography’s strong tradition of field work by featuring prominent nature-society geographers in guest field notes

The Wiley Blackwell Companion to Political Geography aims to account for the intellectual and worldly developments that have taken place in and around political geography in the last 10 years. Bringing together established names in the field as well as new scholars, it highlights provocative theoretical and conceptual debates on political geography from a range of global perspectives. Discusses the latest developments and places increased emphasis on modes of thinking, contested key concepts, and on geopolitics, climate change and terrorism Explores the influence of the practice-based methods in geography and concepts including postcolonialism, feminist geographies, the notion of the Anthropocene, and new understandings of the role of non-human actors in networks of power Offers an accessible introduction to political geography for those in allied fields including political science, international relations, and sociology