Прочая образовательная литература - скачать книги или читать онлайн. Страница 217

Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the insight and advice offered here helps to clear the hurdles in setting up and running a successful analysis, resulting in high-quality data from every experiment. Based on more than a decade of practical experience in developing, optimizing and validating metabolomics approaches as a routine technology in the academic and industrial research laboratory, the lessons taught here are highly relevant for all systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences. From the Contents: * Sampling and Sample Preparation in Microbial Metabolomics * Tandem Mass Spectrometry Hyphenated with HPLC and UHPLC for Targeted Metabolomics * GC-MS, LC-MS, CE-MS and Ultrahigh Resolution MS (FTICR-MS) in Metabolomics * NMR-based metabolomics analysis * Potential of Microfluidics and Single Cell Analysis in Metabolomics * Data Processing in Metabolomics * Validation and Measurement Uncertainty in Metabolomic Studies * Metabolomics and its Role in the Study of Mammalian Systems and in Plant Sciences * Metabolomics in Biotechnology and Nutritional Metabolomics and more.

GIS and Geocomputation for Water Resource Science and Engineering not only provides a comprehensive introduction to the fundamentals of geographic information systems but also demonstrates how GIS and mathematical models can be integrated to develop spatial decision support systems to support water resources planning, management and engineering. The book uses a hands-on active learning approach to introduce fundamental concepts and numerous case-studies are provided to reinforce learning and demonstrate practical aspects. The benefits and challenges of using GIS in environmental and water resources fields are clearly tackled in this book, demonstrating how these technologies can be used to harness increasingly available digital data to develop spatially-oriented sustainable solutions. In addition to providing a strong grounding on fundamentals, the book also demonstrates how GIS can be combined with traditional physics-based and statistical models as well as information-theoretic tools like neural networks and fuzzy set theory.

Hydrodynamics of Time-Periodic Groundwater Flow introduces the emerging topic of periodic fluctuations in groundwater. While classical hydrology has often focused on steady flow conditions, many systems display periodic behavior due to tidal, seasonal, annual, and human influences. Describing and quantifying subsurface hydraulic responses to these influences may be challenging to those who are unfamiliar with periodically forced groundwater systems. The goal of this volume is to present a clear and accessible mathematical introduction to the basic and advanced theory of time-periodic groundwater flow, which is essential for developing a comprehensive knowledge of groundwater hydraulics and groundwater hydrology. Volume highlights include: Overview of time-periodic forcing of groundwater systems Definition of the Boundary Value Problem for harmonic systems in space and time Examples of 1-, 2-, and 3-dimensional flow in various media Attenuation, delay, and gradients, stationary points and flow stagnation Wave propagation and energy transport Hydrodynamics of Time-Periodic Groundwater Flow presents numerous examples and exercises to reinforce the essential elements of the theoretical development, and thus is eminently well suited for self-directed study by undergraduate and graduate students. This volume will be a valuable resource for professionals in Earth and environmental sciences who develop groundwater models., including in the fields of groundwater hydrology, soil physics, hydrogeology, geoscience, geophysics, and geochemistry. Time-periodic phenomena are also encountered in fields other than groundwater flow, such as electronics, heat transport, and chemical diffusion. Thus, students and professionals in the field of chemistry, electronic engineering, and physics will also find this book useful.

The autobiography of a Nobel Prize winner, this book tells us about George Olah's fascinating research into extremely strong superacids and how it yielded the common term «magic acids.» Olah guides us through his long and remarkable journey, from Budapest to Cleveland to Los Angeles, with a stopover in Stockholm. This updated autobiography of a Nobel Prize winner George A. Olah: Chronicles the distinguished career of a chemist whose work in a broad range of chemistry areas, and most notably that in methane chemistry, led to technologies that impact the processing and utility of alternative fuels Is based on Olah's work on extremely strong superacids and how they yielded the common term, «magic acids» Details events since the publication of the first edition in 2000 Inspires readers with details on Dr. Olah's successful recent research on methanol, intended to help provide a solution to «the oil problem»

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

The Terrestrial Water Cycle: Natural and Human-Induced Changes is a comprehensive volume that investigates the changes in the terrestrial water cycle and the natural and anthropogenic factors that cause these changes. This volume brings together recent progress and achievements in large-scale hydrological observations and numerical simulations, specifically in areas such as in situ measurement network, satellite remote sensing and hydrological modeling. Our goal is to extend and deepen our understanding of the changes in the terrestrial water cycle and to shed light on the mechanisms of the changes and their consequences in water resources and human well-being in the context of global change. Volume highlights include: Overview of the changes in the terrestrial water cycle Human alterations of the terrestrial water cycle Recent advances in hydrological measurement and observation Integrated modeling of the terrestrial water cycle The Terrestrial Water Cycle: Natural and Human-Induced Changes will be a valuable resource for students and professionals in the fields of hydrology, water resources, climate change, ecology, geophysics, and geographic sciences. The book will also be attractive to those who have general interests in the terrestrial water cycle, including how and why the cycle changes.

Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.

Molecular Analysis and Genome Discovery, Second Edition is a completely revised and updated new edition of this successful book. The text provides a comprehensive overview of recent developments in the fast moving field of molecular based diagnostics of disease markers. Key concepts and applications are provided alongside practical information on current techniques currently being researched and developed. Each chapter offers an up-to-date analysis of the subject encompassing the very latest technology platforms and is an essential reference for researchers in the field looking for an up-to-date overview of the subject. The book will also be an indispensable resource for those working in the biotechnology and pharmaceutical industries. New for this edition: chapters on Genotyping through Mutation Detection; Differential Gene Expression; Haplotyping and Molecular Profiling.

Based on the '240' Conference held at the University of Chicago in September of 2012, this special volume of The Advances in Chemical Physics series celebrates scientific research contributions and careers of R. Stephen Berry, Stuart A. Rice and Joshua Jortner. In addition to continuing the chemical physics field with a forum for critical, authoritative evaluations of advances in the discipline, Volume 157 explores the following topics: The Emergence and Breakdown of Complexity Dynamics at Extremes Grand Questions Regarding Biomolecular Homochirality in the Origin and Evolution of Life The book: celebrates the scientific research contributions and careers of R. Stephen Berry, Stuart A. Rice and Joshua Jortner contributes to the only series available that presents the cutting edge of research in chemical physics includes contributions from experts in this field of research structured with an editorial framework that makes the book an excellent supplement to an advanced graduate class in physical chemistry or chemical physics

Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.

Expanded and updated with new findings and new features New chapter on Global Climate providing a self-contained treatment of climate forcing, feedbacks, and climate sensitivity New chapter on Atmospheric Organic Aerosols and new treatment of the statistical method of Positive Matrix Factorization Updated treatments of physical meteorology, atmospheric nucleation, aerosol-cloud relationships, chemistry of biogenic hydrocarbons Each topic developed from the fundamental science to the point of application to real-world problems New problems at an introductory level to aid in classroom teaching

The chapters in this volume explore ultrasound-assisted regeneration of silica gel, ultrasound-assisted regeneration for a new honeycomb desiccant material, ultrasound-atomizing regeneration for liquid desiccants, ultrasonic transducers, and much more.