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A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis. Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features: Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials Over 100 contributions from leading academics, researchers, and practitioners An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.

There has been a surge in «Living Labs» in recent years including those focusing on the health and autonomy sectors. The aim of these innovative user-centered spaces is the emergence of products and services that meet market needs and support both the efficiency of public health and the competitiveness of enterprises. This book is the result of work involving both field practitioners and academic actors in human sciences and co-design. It highlights the good practices that arise within living labs despite their use of different approaches. This collaborative work has given rise to the Living Lab Health and Autonomy (LLSA) Forum and has allowed for an improved capacity to support an efficient development of this form of design for the actors of health and autonomy, but also of industry and of its investors. This book draws on their experience and the views of experts to illuminate their practices and gives better visibility and legibility to these new players.

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

Test your knowledge or prepare for Boards with this collection of unusual and challenging patient studies focused on detecting valvular, congenital or vascular disease. Contains over 90 case histories with self-test questions designed to test the reader’s knowledge and reinforce clinical best practices Focuses on diseases of valvular, vascular or congenital origin, and on comparatively rare disorders/diseases, rather than coronary artery disease, to help readers improve their skills at interpreting and making decisions based on physical examination and basic, non-invasive imaging modalities Each case is paired with original materials – e.g. x-rays, echocardiograms, lab reports, charts – so readers can work through their diagnosis using the same information as the physician who treated the patient originally An ideal companion for those approaching board review or recertification or who want to improve skills in physical diagnosis of cardiovascular disease

Learn the essentials of finance theory and practice with the tools needed in day-to-day practice In this thoroughly revised and updated fourth edition of Fundamentals of Health Care Financial Management, consultant and educator Steven Berger offers a practical step-by-step approach to understanding the fundamental theories and relationships guiding financial decisions in health care organization. Using cases set in a fictional mid-sized hospital, the book takes the reader into the inner workings of the finance executive's office. As in the previous editions, this book introduces students to key practical concepts in fundamental areas of financial management. This innovative introduction to the most-used tools and techniques includes health care accounting and financial statements; managing cash, billings and collections; making major capital investments; determining cost and using cost information in decision-making; budgeting and performance measurement; and pricing. Also covered in depth are the financial implications of Patient Protection and Affordable Care Act, which will increase patient volume, reduce bad debt, factor quality and patient satisfaction into the financial picture, and significantly affect how hospitals and physicians are paid for services. Students focusing on the business side of health care will find Fundamentals of Health Care Financial Management: A Practical Guide to Fiscal Issues and Activities, 4th Edition a valuable text for understanding the workings of the health care financial system.

Local and Regional Flaps in Head & Neck Reconstruction: A Practical Approach provides comprehensive, step-by-step instruction for flap raising and insetting for the head and neck region. Ideal for oral and maxillofacial surgeons, facial plastic surgeons, and head and neck surgeons, the book serves as a useful guide to planning reconstructive cases and an easily accessible reference prior to operation. Local and Regional Flaps in Head & Neck Reconstruction is logically organized into 24 chapters, each focusing on a local or regional flap, or a special site reconstruction. Chapters focused on a particular flap will begin with a detailed description of the relevant anatomy and discuss potential applications of the flap before moving into a detailed step-by-step description of how to elevated and transfer the flap to the defect site. Potential complications will also be addressed. Well-illustrated with more than 800 clinical photographs and with a website featuring surgical procedures, this book is an ideal reference for those new to practice and experts alike.

This unique new guide integrates recent advances in the biopsychosocial understanding of chronic pain with state-of-the-art cognitive therapy and mindfulness techniques to offer a fresh, highly-effective MBCT approach to helping individuals manage chronic pain. There is intense interest from clinicians, researchers and patients alike in mindfulness-based therapeutic techniques, and the integration of mindfulness theory and practice with CBT Provides everything a therapist needs to integrate MBCT into their practice and optimize its delivery, including a manualized 8-session program and guidance on how to teach MBCT skills Features case studies and real-world examples that help practitioners to avoid common pitfalls and optimize the delivery of MBCT for chronic pain for their own individual clients Features links to guided meditations, client and therapist handouts and other powerful tools

Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: • Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems • Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index • Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials

Since its introduction to dentistry, cone beam computed tomography (CBCT) has undergone a rapid evolution and considerable integration into orthodontics. However, despite the increasing popularity of CBCT and progress in applying it to clinical orthodontics, the profession has lacked a cohesive, comprehensive and objective reference that provides clinicians with the background needed to utilize this technology optimally for treating their patients. Cone Beam Computed Tomography in Orthodontics provides timely, impartial, and state-of-the-art information on the indications and protocols for CBCT imaging in orthodontics, clinical insights gained from these images, and innovations driven by these insights. As such, it is the most current and authoritative textbook on CBCT in orthodontics. Additionally, two DVDs include more than 15 hours of video presentations on related subjects from the 39th Annual Moyers Symposium and 38th Annual International Conference on Craniofacial Research. Cone Beam Computed Tomography in Orthodontics is organized to progress sequentially through specific topics so as to build the knowledgebase logically in this important and rapidly evolving field. Part I provides the foundational information on CBCT technology, including radiation exposure and risks, and future evolutions in computed tomography. Part II presents the Principles and Protocols for CBCT Imaging in Orthodontics, focusing on developing evidence-based criteria for CBCT imaging, the medico-legal implications of CBCT to the professional and the protocols and integration of this technology in orthodontic practice. Part III provides critical information on CBCT-based Diagnosis and Treatment Planning that includes how to interpret CBCT scans, identify incidental pathologies and the possible other uses of this technology. Part IV covers practical aspects of CBCT’s Clinical Applications and Treatment Outcomes that encompasses a range of topics, including root morphology and position, treatment of impacted teeth, virtual surgical treatment planning and outcomes, and more.

Neonatal Formulary is a unique publication that provides comprehensive guidance on the safe use of all the drugs prescribed during pregnancy and commonly given to babies during labour, delivery, and the first year of life. This new edition provides improved and detailed coverage of the many drugs that are given to women during pregnancy and during lactation where the baby's welfare must be borne in mind as well as that of the mother. Thus the whole 'pregnancy through to parenthood' journey is treated as a continuous event with information about drug use and the effects of drugs at all stages of the development from fetus to infant. Containing far more detail than is available in the British National Formulary for Children and with a companion website featuring updates related to specific drugs and dosing, Neonatal Formulary is an essential guide for neonatologists, neonatal nurses, hospital pharmacists, obstetric staff, advanced nurse practitioners and for all health care professionals caring for pregnant women and their infants in the first year of life. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.