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Blackwell’s Five-Minute Veterinary Consult: Avian presents complete information on diseases and conditions seen in birds in a quick-reference format ideal for clinical practice. • Offers fast access to essential information on 128 avian diseases and syndromes • Written by leading experts in avian medicine • Uses the trusted Five-Minute Veterinary Consult format • Focuses on practical clinical knowledge • Includes access to a companion website offering algorithms, procedure guides, and client education handouts to download, edit, and use in practice

Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Canine and Feline Behavior, Second Edition offers fast access to reliable, practical information on managing common behavior disorders in dogs and cats. Takes a new section approach to allow for easier browsing Adds 19 new topics or algorithms covering separation anxiety, thunderstorm sensitivity, introducing pets to the family and each other, enrichment, geriatric behavior problems, handling techniques, urine marking, leash reactivity, pediatric behavior problems and best practices, and rescue pets Offers a comprehensive guide to diagnosing and managing behavior problems in dogs and cats Designed for fast access to information, with identically formatted topics for ease of use Includes access to a companion website providing 43 client education handouts for download and use, including 25 brand-new handouts

This highly illustrated, diagnostic guidebook provides a single comprehensive source of essential information to enable non-specialists to diagnose lymph node and related diseases with confidence. The text is didactic and practical, covering reactive as well as malignant conditions. Diagnosis of Lymphoproliferative Diseases approaches the disorders based on the WHO classification and is edited by members of the WHO panel for the classification of lymphomas. This second edition contains over 1000 high quality, digitised colour images and tables of essential criteria for each diagnosis. New features include: Full discussion of immunostaining, the core of modern diagnosis Variant forms and technical issues This authoritative guide is an essential reference for haematologists, haematopathologists, general pathologists, diagnostic histopathologists and oncologists.

The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world. Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care. Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the TNM Classification of Malignant Tumours. The ninth edition includes: Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments, Representation of multidisciplinary care for site specific management, Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines, State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy. Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.

Now in its fifth edition, Pharmacoepidemiology defines the discipline and provides the most comprehensive guidance of any book on the topic. Written by world renowned experts in the field, this valuable text surveys the research designs and sources of data available for pharmacoepidemiologic research, and provides descriptions of various automated data systems, along with the advantages and disadvantages of each. Incorporating perspectives from academia, industry and regulatory agencies, this book provides detailed insights into all aspects of pharmacoepidemiology.

There have been many advances in the management of this condition since the first edition of Gastrointestinal Bleeding. This new edition, thoroughly revised and restructured, includes the latest updates on all areas of the field of GI Bleeding, systematically covering all the areas of the GI tract, from upper GI to lower GI, through to small bowel bleeding. It fully covers the different types of bleeding that can occur, from peptic ulcer through to variceal bleeding and looks at new developments and pioneering techniques in the field, including endoscopy and balloon-enteroscopy. A methodology section describes the latest design of clinical trials in GI bleeding and this edition now highlights the new guidelines on UGIB (Upper gastrointestinal bleeding). This new edition of Gastrointestinal Bleeding is an invaluable purchase for all gastroenterologists, both in training and fully qualified.

This is a major new work dedicated to the increasingly prominent area of adult orthodontics. Written by renowned contributors from the orthodontic community and beyond, and compiled by a world-class editor, it provides an authoritative resource on the subject, marrying together clinical guidance with a thorough evaluation of the evidence base. The opening chapters provide the context for adult orthodontics, including patient demographics and aetiology, and the book goes on to detail treatment planning considerations, including patient case profiles, suggesting initial outcomes and longer term expectations. Interdisciplinary and multidisciplinary approaches are discussed, including the links between adult orthodontics and periodontics, prosthetics and temporomandibular disorders. The book is accompanied by a website containing further examples of case studies and a wealth of clinical images. Set to become the gold standard resource on the subject, this book will be invaluable to all those providing orthodontic treatment to adults and those dealing with orthodontics as part of the inter-disciplinary management of the adult dentition. KEY FEATURES • A major new work on an expanding area of orthodontic treatment • Covers patient demographics, aetiology, treatment planning and maintenance issues • Includes case studies, suggesting realistic and optimal short and long term outcomes • Highly illustrated with full colour clinical photos • Accompanied by a website with further material: www.wiley.com/go/melsen

With the development of new instruments and the refining of new techniques, flexible bronchoscopy has become one of the most frequently performed invasive procedures in pulmonary medicine. This new edition of Flexible Bronchoscopy is an essential addition to the bronchoscopist's bookshelf. It highlights possible complications, contra-indications and precautions. In addition it addresses all current techniques and future technologies in interventional bronchoscopy. For ease of use Flexible Bronchoscopy is divided into four major sections: Fundamentals of Bronchoscopy Diagnostic Bronchoscopy Therapeutic Bronchoscopy Special Considerations Flexible Bronchoscopyis an ideal training manual for all respiratory and pulmonary physicians, as well as trainees and residents working in the field of respiratory medicine, who need to develop the skill of interventional bronchoscopy.

This best selling text has been completely revised and refreshed in the fourth edition. The authors aim to enthuse family doctors (for whom they are primarily writing) to enjoy the challenge of diagnosing and treating skin conditions. Clinical Dermatology contains over 500 high quality pictures and diagrams matched with many colourful phrases to illustrate and entertain as it teaches. It has established a reputation as a ‘way of learning’ and as a cogent overview of the subject for the aspiring specialist. Readers are guided through the maze that too often lies between the presenting skin complaint and its final diagnosis and treatment. The authors have created an easily read text with enough detail to clarify the subject but not enough to obscure it. This fourth edition contains new chapters on racially pigmented skin, dermatology of different age groups and cosmetic dermatology. Relevant internet sites are now clearly highlighted at the end of each chapter and the comprehensive formulary has been updated.

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.